diff --git a/.first_sentences.txt.kate-swp b/.first_sentences.txt.kate-swp deleted file mode 100644 index a4cc395..0000000 Binary files a/.first_sentences.txt.kate-swp and /dev/null differ diff --git a/1-s2.0-S0939388921001082-main_HIT_experimental_area_OJ.pdf b/1-s2.0-S0939388921001082-main_HIT_experimental_area_OJ.pdf new file mode 100644 index 0000000..c5621fb Binary files /dev/null and b/1-s2.0-S0939388921001082-main_HIT_experimental_area_OJ.pdf differ diff --git a/Bewerbung_Carl_Zeiss_Stipendium_SW.pdf b/Bewerbung_Carl_Zeiss_Stipendium_SW.pdf new file mode 100644 index 0000000..b380cfa Binary files /dev/null and b/Bewerbung_Carl_Zeiss_Stipendium_SW.pdf differ diff --git a/anke_fragen.txt b/anke_fragen.txt index 5455f79..23920f2 100644 --- a/anke_fragen.txt +++ b/anke_fragen.txt @@ -84,5 +84,75 @@ LET abhängig +----------------------------- +ERIK -mal für erik formuliert: Ganz grob gesagt ist der Themenbereich den ich überlege zu bearbeiten, den Überlap beziehungsweise die Verknüpfung von Beschleuniger Simulationen mit Strahltransportsimulationen in Materie weiter zu verstärken. Insbesondere der Einfluss von kollektiven Effekten bei Strahlen mit den extremen Eigenschaften wie die kurzen, intensiven Pulse für FLASH oder auch räumlich modulierte Strahlen (daher auch das Interesse am SLM). Beim Transport der Strahlen durch Luft und Materie wird momentan in den aller meisten Fällen die Interaktion von Strahl-Teilchen miteinander nicht berücksichtigt. Das ganze würde ich unterstützen durch experimentelle Messungen (Strahleigenschaften und Dosimetry) und auch Tests von möglichen neuen Detektortypen für Dosimetry (wenn sich da Kollaborationen ergeben). + + + + + +geral major heidelberg +ingrid birke slac? +clara bei cern +mad see tomographie martin frank scc inverse probleme, sb waves? +bildgebung, ka see school +artem + +wie genau kosten auf schlüsseln? +Mit plots/graphiken von anderen leuten? oder selber alles machen? +oder nur die eigenen? + + +verschiedenen arbeitspackete? oder nur die unterteilung in die geplanten personen? packete laufen dann nicht immer ide ganze laufzeit + +was rein schreiben bei geplanter projekt dauer... einfach nur 6 jahre? sehr kurz + + +noch punkte für data handling? ?vielleicht ihm schicken? +wie sind die kosten für laptops und so? was wird vom institute gestellt? + + + +kollaborierende wissenschaftler auch vom kit auflisten? oder ist das impliziert? auch interne vernetzung, ipe kollaboration über publikation nachweisen + + +was für travel expenses ansetzten + +hydro gel am kit + +S1 und S2 infrastruktur, sicherheitsstufen am kit veronice, maus haus + + +mems modulatoren, slm nur eine möglichkeit schon vorhanden + +grafik, für struktur für module.... + +einschub fenstern messung, fenster, wieder vaccum, faraday cup + +auch keine detektoren für gepulste strahlen für strahlenschutz....also auch für tüv + +!!schwer punkt auch gepulste und kurze pulse legen, da mehr verstehen, hab viel erfahrung, auch auslesemöglichkeiten (bisher CW elektrometer) aber wir haben ja mehr, aber keine zeitauflösung +und detektoren... + + +armin abdulla experte on detector +vs chow seko + +matthias fuchs + +dielam ipe protonen am zyklotron, +e/judat instanz b2share, chenran und andrea + +standard medizin experimente darum ptw oder ähnlich gegenkallibrieren +KIT SUM, und geschichte kernforschungseinrichtung, strahlenschutz hoch und eichkallibrierungs sachen + +datascience, computing,....phd auch 100% sehr interdisciplinär + +tumoride 3D ude schäffers, + +!comparative studies are envisioned at HIT heidelberg experimentelle area + +GSI FLASH, lennart fragen ob collaborieren? + +Ganz grob gesagt ist der Themenbereich den ich überlege zu bearbeiten, den Überlap beziehungsweise die Verknüpfung von Beschleuniger Simulationen mit Strahltransportsimulationen in Materie weiter zu verstärken. Insbesondere der Einfluss von kollektiven Effekten bei Strahlen mit den extremen Eigenschaften wie die kurzen, intensiven Pulse für FLASH oder auch räumlich modulierte Strahlen (daher auch das Interesse am SLM). Beim Transport der Strahlen durch Luft und Materie wird momentan in den aller meisten Fällen die Interaktion von Strahl-Teilchen untereinander nicht berücksichtigt. Das ganze würde ich unterstützen durch experimentelle Messungen (Strahleigenschaften und Dosimetry) und auch Tests von möglichen neuen Detektortypen für Dosimetry (wenn sich da Kollaborationen ergeben). diff --git a/emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf# b/emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf# index d114f49..bac480f 100644 --- a/emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf# +++ b/emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf# @@ -1 +1 @@ -,mirbro,w-mirbro-pc-0,11.01.2024 12:02,file:///home/mirbro/.config/libreoffice/4; \ No newline at end of file +,mirbro,w-mirbro-pc-0,12.01.2024 00:50,file:///home/mirbro/.config/libreoffice/4; \ No newline at end of file diff --git a/emmy_noether/53_05_en_elan_projectdescription_draft.rtf b/emmy_noether/53_05_en_elan_projectdescription_draft.rtf index 3ab6ee2..ee48804 100644 --- a/emmy_noether/53_05_en_elan_projectdescription_draft.rtf +++ b/emmy_noether/53_05_en_elan_projectdescription_draft.rtf @@ -478,12 +478,12 @@ {\listlevel\levelnfc255\leveljc0\levelstartat1\levelfollow2{\leveltext \'00;}{\levelnumbers;}\fi0\li0} {\listlevel\levelnfc255\leveljc0\levelstartat1\levelfollow2{\leveltext \'00;}{\levelnumbers;}\fi0\li0} {\listlevel\levelnfc255\leveljc0\levelstartat1\levelfollow2{\leveltext \'00;}{\levelnumbers;}\fi0\li0}\listid2} -}{\listoverridetable{\listoverride\listid1\listoverridecount0\ls1}{\listoverride\listid2\listoverridecount0\ls2}}{\*\generator LibreOffice/7.3.7.2$Linux_X86_64 LibreOffice_project/30$Build-2}{\info{\*\company DFG}{\author strauss}{\creatim\yr2019\mo1\dy21\hr11\min46}{\revtim\yr2024\mo1\dy11\hr12\min2}{\printim\yr2011\mo7\dy6\hr8\min48}}{\*\userprops{\propname Operator}\proptype30{\staticval westermann}}\deftab708\deftab708\deftab708\deftab708\deftab708 -\hyphauto1\viewscale120 +}{\listoverridetable{\listoverride\listid1\listoverridecount0\ls1}{\listoverride\listid2\listoverridecount0\ls2}}{\*\generator LibreOffice/7.3.7.2$Linux_X86_64 LibreOffice_project/30$Build-2}{\info{\*\company DFG}{\author strauss}{\creatim\yr2019\mo1\dy21\hr11\min46}{\revtim\yr2024\mo1\dy12\hr0\min49}{\printim\yr2011\mo7\dy6\hr8\min48}}{\*\userprops{\propname Operator}\proptype30{\staticval westermann}}\deftab708\deftab708\deftab708\deftab708\deftab708 +\hyphauto1\viewscale160 {\*\pgdsctbl {\pgdsc0\pgdscuse451\pgwsxn11906\pghsxn16838\marglsxn1418\margrsxn1134\margtsxn1418\headery709\margbsxn851{\header\pard\plain \s436\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tqc\tx4536\tqr\tx9072\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\tqc\tx4536\tqr\tx9072\li0\ri0\lin0\rin0\fi0{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch DFG form 53.05 \u8211\'96 09/22\tab \tab page }{\rtlch\af16\afs17 \ltrch\lang1033\langfe1033\loch\fs17\lang1033\b0\dbch\langfe1033\loch -{\field{\*\fldinst PAGE }{\fldrslt 16}}}{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch +{\field{\*\fldinst PAGE }{\fldrslt 2}}}{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch of max. 17} \par \pard\plain \s436\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tqc\tx4536\tqr\tx9072\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\tqc\tx4536\tqr\tx9072\li0\ri0\lin0\rin0\fi0\loch\lang2057\b0\loch @@ -491,7 +491,7 @@ DFG form 53.05 \u8211\'96 09/22\tab \tab page }{\rtlch\af16\afs17 \ltrch\lang103 {\pgdsc1\pgdscuse451\pgndec\pgwsxn11906\pghsxn16838\marglsxn1134\margrsxn567\margtsxn567\margbsxn567\pgdscnxt1 HTML;}} \formshade\paperh16838\paperw11906\margl1418\margr1134\margt709\margb851\sectd\sbknone\pgndec\sftnnar\saftnnrlc\sectunlocked1\pgwsxn11906\pghsxn16838\marglsxn1418\margrsxn1134\margtsxn1418\headery709\margbsxn851{\header\pard\plain \s436\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tqc\tx4536\tqr\tx9072\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\tqc\tx4536\tqr\tx9072\li0\ri0\lin0\rin0\fi0{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch DFG form 53.05 \u8211\'96 09/22\tab \tab page }{\rtlch\af16\afs17 \ltrch\lang1033\langfe1033\loch\fs17\lang1033\b0\dbch\langfe1033\loch -{\field{\*\fldinst PAGE }{\fldrslt 16}}}{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch +{\field{\*\fldinst PAGE }{\fldrslt 2}}}{\rtlch\af16\afs17 \ltrch\lang2057\loch\fs17\lang2057\b0\loch of max. 17} \par \pard\plain \s436\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tqc\tx4536\tqr\tx9072\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\tqc\tx4536\tqr\tx9072\li0\ri0\lin0\rin0\fi0\loch\lang2057\b0\loch @@ -503,17 +503,38 @@ Project Description \u8211\'96 Emmy Noether Programme} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\loch -Miriam Katharina Brosi, [city]} +Miriam Katharina Brosi, [city}{\loch\lang1033\loch +Lund/Karlsruhe?}{\loch\lang1033\loch +]} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang2057\loch -[Project title]} +B}{\loch\lang2057\loch +eam }{\loch\lang2057\loch +D}{\loch\lang2057\loch +ynamics and }{\loch\lang2057\loch +C}{\loch\lang2057\loch +ollective }{\loch\lang2057\loch +E}{\loch\lang2057\loch +ffects in }{\loch\lang2057\loch +S}{\loch\lang2057\loch +tructured }{\loch\lang2057\loch +B}{\loch\lang2057\loch +eams for }{\loch\lang2057\loch +A}{\loch\lang2057\loch +dvanced }{\loch\lang2057\loch +A}{\loch\lang2057\loch +ccelerator based }{\loch\lang2057\loch +R}{\loch\lang2057\loch +adiation }{\loch\lang2057\loch +T}{\loch\lang2057\loch +herapy} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\brdrb\brdrs\brdrw10\brdrcf1\brsp20\rtlch\afs22 \ltrch\lang2057\loch\lang2057\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs22 \ltrch\lang2057\loch\lang2057\b0\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang2057\loch -{\*\bkmkstart _Toc283039039}{\*\bkmkstart _Toc2867618961}{\*\bkmkstart _Toc283017236}{\*\bkmkstart _Toc283038945}{\*\bkmkstart _Toc283017362}{\*\bkmkend _Toc283039039}{\*\bkmkend _Toc2867618961}{\*\bkmkend _Toc283017236}{\*\bkmkend _Toc283038945}{\*\bkmkend _Toc283017362}Project Description} +{\*\bkmkstart _Toc2867618961}{\*\bkmkstart _Toc283039039}{\*\bkmkstart _Toc283017236}{\*\bkmkstart _Toc283038945}{\*\bkmkstart _Toc283017362}{\*\bkmkend _Toc2867618961}{\*\bkmkend _Toc283039039}{\*\bkmkend _Toc283017236}{\*\bkmkend _Toc283038945}{\*\bkmkend _Toc283017362}Project Description} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\fs18\lang2057\i\b0\loch Sections 1-3 must not exceed 17 pages in total.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\af16\afs22 \ltrch\lang2057\loch\lang2057\b0\loch @@ -526,7 +547,7 @@ Starting Point} State of the art and preliminary work} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\b0\loch -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch Radiotherapy }{\loch\lang1033\b0\loch (RT) }{\loch\lang1033\b0\loch has been }{\loch\lang1033\b0\loch @@ -539,53 +560,274 @@ over the years, RT}{\loch\lang1033\b0\loch towards }{\loch\lang1033\b0\loch a }{\loch\lang1033\b0\loch successful and well tolerable treatment of cancer by reducing side effects while maintaining or even enhancing treatment efficacy in the future and improving the quality of life of the patients. } -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -Scientific and technological advances in a broad spectrum of scientific disciplines are an important cornerstone for such developments }{\loch\lang1033\b0\loch -due to the high performance requirements on the used technologies. } -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -Radiotherapy uses ionizing radiation to damage the DNA within the tumor cells, which prevents the cells from reproducing and eventually leads to their death. One common approach employs high-energy beams of particle or photon to irradiate the cancer cells and shrink or destroy the tumors. This targeted approach minimizes damage to healthy tissues while effectively treating the affected area. } -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\b0\loch +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +In Europe, radiotherapy is recommended as part of the treatment plan for around 50% of cancer patients}{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -2017370845}\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch + Josep M. Borras, Yolande Lievens & Cai Grau (2015) The need for radiotherapy in Europe in 2020: Not only data but also a cancer plan, Acta Oncologica, 54:9, 1268-1274, DOI: 10.3109/0284186X.2015.1062139 }}}{\loch\lang1033\b0\loch +.}{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -2017371356}\loch\cf20\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch + In the EU, more than 3,000 medical accelerators are in use for RT, and in}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +Germany, more than 250,000 patients receive RT as part of their cancer treatment each year.}}} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Scientific and technological advances in a broad spectrum of scientific disciplines are an important cornerstone for developments }{\loch\lang1033\b0\loch +in radiotherapy due to the high performance requirements on the used technologies. Radiotherapy uses ionizing radiation to damage the DNA within the tumor cells, which prevents the cells from reproducing and eventually leads to their death. One common approach employs high-energy beams of particles or x-rays to irradiate the cancer cells and shrink or destroy the tumors. This non-invasive, targeted approach focuses on delivering a precise and targeted dose of ionizing radiation directly to the affected area, minimizing damage to healthy tissues while effectively treating the selected area. } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +As still small areas of healthy tissue is irradiated in order to ensure the treatment of all cancerous cells, }{\loch\lang1033\b0\loch +an accurate control of the }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +dose rate }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +is required}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +to keep a balance }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +between tumor control and normal tissue tolerance. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +The }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +range }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +between}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + radiation doses that effectively destroy cancer cells while }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +only causing minimal }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +damage to healthy tissues and organs }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +is called the therapeutic window.}{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -2017370960}\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\af18\ab0\afs24\ai0\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\strike0\i0\accnone\scaps0\caps0\b0\cf1\charscalex100\fs20\lang1033\outl0\f3\expnd0\expndtw0\ulnone\ulc0\kerning0\shad0\dbch\langfe2052\af21\loch +. The therapeutic}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\ai0\afs24\ab0\af18 \ltrch\lang1033\langfe2052\hich\af3\loch\shad0\kerning0\ulnone\ulc0\expnd0\expndtw0\f3\outl0\lang1033\fs20\charscalex100\cf1\b0\scaps0\caps0\accnone\i0\strike0\dbch\af21\langfe2052\loch +window is the dose region between the normal tissue complication}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\af18\ab0\afs24\ai0\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\strike0\i0\accnone\scaps0\caps0\b0\cf1\charscalex100\fs20\lang1033\outl0\f3\expnd0\expndtw0\ulnone\ulc0\kerning0\shad0\dbch\langfe2052\af21\loch +probability (NTCP) and the tumour control probability (TCP) curves}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\ai0\afs24\ab0\af18 \ltrch\lang1033\langfe2052\hich\af3\loch\shad0\kerning0\ulnone\ulc0\expnd0\expndtw0\f3\outl0\lang1033\fs20\charscalex100\cf1\b0\scaps0\caps0\accnone\i0\strike0\dbch\af21\langfe2052\loch +(Fig. 1); \uc3 \u8220\'e2\'80\'9ctowards clinical FLASH\u8221\'e2\'80\'9d\uc1 }}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +In conventional radiotherapy, t}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +his }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +requires a}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + carefully balancing }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +of }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +the number of fractions (dose sessions) and }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +the}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + dose per fraction to achieve optimal results }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +and avoiding}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + excessive harm to nearby healthy tissues. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +A }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +widening }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +of }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +this window is }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +one of the }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +main goal}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +s}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + of radiotherapy research. } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +The external beam radiotherapy (EBRT) is based on particle accelerators to produce the high-energy beams, which can range from x-rays over electrons and protons to }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +helium and carbon}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + ions. The different beam types offer different advantages in their interaction with matter. Photon (x-ray) radiotherapy is the most common form and has been widely studied. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +Beam e}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +nergies can range from low energies around 100 keV for superficial treatment up to energies as high as 4 to 25 MeV for treatments of }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +larger }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +tumors deep within the body. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +More than 90% of radiotherapy patients receive high-energy X-rays produced by bremsstrahlung of electrons accelerated in linear accelerators. The direct usage of }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +electrons is limited }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +to more superficial treatments }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +as they only penetrate a few centimeters into tissue before losing energy. This makes electron radiotherapy particularly suitable for treating superficial or shallow tumors such as skin or lymphoma cancer, while sparing deeper organs. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +Heavier particles like protons or ions }{\loch\lang1033\b0\loch +deposit most of their energy }{\loch\lang1033\b0\loch +immediately before}{\loch\lang1033\b0\loch + the end of their path through }{\loch\lang1033\b0\loch +the}{\loch\lang1033\b0\loch + tissue }{\loch\lang1033\b0\loch +(Bragg peak)}{\loch\lang1033\b0\loch +, resulting in reduced damage to healthy tissues }{\loch\lang1033\b0\loch +before and }{\loch\lang1033\b0\loch +beyond the target area. This makes proton }{\loch\lang1033\b0\loch +and ion}{\loch\lang1033\b0\loch + therapy particularly useful for treating deep tumors or those near critical structures. T}{\loch\lang1033\b0\loch +he requirements on stability and reproducibility of the accelerators providing the radiation beams are very high to ensure that the dose applied to the patient is within }{\loch\cf20\lang1033\b0\loch +1/5%}{\loch\lang1033\b0\loch + of the prescribed treatment dose. Therefore precise calibration and dosimetry measurements are required and national standards are defined. For conventional RT the }{\loch\lang1033\b0\loch +primary}{\loch\lang1033\b0\loch + standard }{\loch\lang1033\b0\loch +have been defined by several national metrology institutions. For conventional MeV electron beams the Fricke dosimetry method is used as primary standard for absorbed dose to water}{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -1480499198}\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +@article\{H Feist_1989,}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +doi = \{10.1088/0031-9155/34/12/009\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +url = \{https://dx.doi.org/10.1088/0031-9155/34/12/009\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +year = \{1989\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +month = \{dec\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +publisher = \{\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +volume = \{34\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +number = \{12\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +pages = \{1863\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +author = \{H Feist and U Muller\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +title = \{Measurement of the total stopping power of 5.3 MeV electrons in polystyrene by means of electron beam absorption in ferrous sulphate solution\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +journal = \{Physics in Medicine & Biology\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +abstract = \{Describes how an experimental arrangement for the calibration of Fricke solution in terms of absorbed dose to water can be utilised to determine total, i.e. collisional and radiative, mass stopping power of high-energy electrons. As a first result the measurement of the total mass stopping power of polystyrene at about 5.3 MeV kinetic electron energy is presented in detail. Comparison of the obtained value with the corresponding result of recent theoretical computations shows agreement within the measurement uncertainty of about 1.2% (SD).\}}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +\}}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}}}{\loch\lang1033\b0\loch +. For proton therapy dosimetry, graphite calorimeters have been well established as primary standard level instruments.}{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -1480499189}\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +@article\{Seuntjens_2009,}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +doi = \{10.1088/0026-1394/46/2/S04\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +url = \{https://dx.doi.org/10.1088/0026-1394/46/2/S04\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +year = \{2009\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +month = \{mar\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +publisher = \{\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +volume = \{46\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +number = \{2\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +pages = \{S39\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +author = \{Jan Seuntjens and Simon Duane\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +title = \{Photon absorbed dose standards\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +journal = \{Metrologia\},}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +abstract = \{In this review the current status of absorbed dose to water standards for high-energy photon beams (60Co\uc3 \u8212\'e2\'80\'9450\u8201\'e2\'80\'89MV nominal accelerating potential) is discussed. The review is focused on calorimeter-based absorbed dose standards for photon radiation therapy calibrations with typical dose rates of a few gray per minute. In addition, two alternative types of absorbed dose standards are also discussed. The overall uncertainty on measured dose to water in static reference fields is nowadays on the order of 0.4% to 0.5%. The components contributing to the uncertainty budgets are discussed. The discussed absorbed dose to water standards are expected to continue to have their place not only in the dissemination of absorbed dose to water but also in the determination of beam quality conversion factors essential in reference dosimetry in high-energy photon beams.\}\uc1 }\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af20\loch +\}}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}}}{\loch\lang1033\b0\loch + } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +A}{\loch\lang1033\b0\loch +dvancement}{\loch\lang1033\b0\loch +s}{\loch\lang1033\b0\loch + and new concepts of treatment }{\loch\lang1033\b0\loch +and beam }{\loch\lang1033\b0\loch +modalities in }{\loch\lang1033\b0\loch +radiotherapy lead to }{\loch\lang1033\b0\loch +increasing requirements on }{\loch\lang1033\b0\loch +dosimetry and}{\loch\lang1033\b0\loch + }{\loch\lang1033\b0\loch +as well as on the diagnostics and understanding of the beam dynamics in the }{\loch\lang1033\b0\loch +accelerator}{\loch\lang1033\b0\loch +s used for beam generation. Especially for new approaches including either temporally or spatially modulated beams, new effects might need to be considered in the examination and simulation of the beams and their generation. T}{\loch\cf20\lang1033\b0\loch +wo ne}{\loch\lang1033\b0\loch +w approaches to radiotherapy have received considerable attention in the last years and are investigated in preclinical trials. } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +--------} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +FLASH RT is a novel approach focuses on delivering very high doses in an ultra-short time frame, typically within milliseconds or less. This technique aims to exploit the unique properties of these short pulses to enhance tumor cell killing while minimizing damage to surrounding healthy tissues. } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Number???? >=40Gy/s with pulse length <500ms and total doses of >= 10Gy opposed to 1.8-2Gy per fraction in 30 fractions with a dose rate of 0.2-20Gy/min. }{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -1480499167}\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\ai0\ab0\afs24\af18\alang1081 \ltrch\langfe2052\lang1033\hich\af3\loch\fs20\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\f3\dbch\af20\langfe2052\loch +Paper GSI}}} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +FLASH effect\u8230\'85.very short exposure time with high dose, increases significantly therapeutic window\u8230\'85.} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Reported that Works for all typical radiation modalities used in RT} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -External Beam Radiation Therapy (EBRT), also known as external radiotherapy is a type of cancer treatment that uses high-energy rays to destroy cancer cells and shrink tumors. It works by damaging the DNA within these cells, which prevents them from reproducing and eventually leads to their death. This targeted approach minimizes damage to healthy tissues while effectively treating the affected area.} +The primary advantage of FLASH radiotherapy is its ability to achieve significantly higher doses than conventional radiation therapy without causing severe side effects, such as acute normal tissue reactions or long-term complications. This increased efficacy may lead to improved treatment outcomes and reduced overall toxicity for patients with various types of cancer.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -Cancer } +Also much more effective and less treatment time necessary per patient\u8230\'85.} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -RT important,} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 - }{\loch\lang1033\b0\loch -most rely on accelerator, e, oder pro oder ion, und xrays also from e. with advancement of treatment modalities in RT come more challanging requeiremets on acclerator beam. So now more complex dynamics and studies important, espectially for flash and mrt beams, as there vom accelerator perspective collective effect important. } -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -[Text] Verst\u228\'e4ndlich erkl\u228\'e4ren:} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -RT}{\rtlch\afs28 \ltrch\lang1033\loch\cf20\lang1033\b0\loch - }{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203850170}\loch\cf20\sl240\slmult1\loch{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\i0\ab0\loch -\uc3 \u65279\'ef\'bb\'bfExternal Beam Radiation Therapy (EBRT), also known as external radiotherapy is a type of cancer treatment that uses high-energy rays to destroy cancer cells and shrink tumors. It works by damaging the DNA within these cells, which prevents them from reproducing and eventually leads to their death. This targeted approach minimizes damage to healthy tissues while effectively treating the affected area.\uc1 }}} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -doserate??} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -tolerability, therapeutic window} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -electron RT}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203850171}\loch\sl240\slmult1\loch{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\i0\ab0\loch -\uc3 \u65279\'ef\'bb\'bfElectron Beam Radiation Therapy (EBRT) is a type of external beam radiotherapy that uses high-energy electrons to treat cancerous tumors in the body. This non-invasive treatment method focuses on delivering a precise and targeted dose of ionizing radiation directly to the affected area, minimizing damage to surrounding healthy tissues.\uc1 }\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -One advantage of EBRT over other radiation therapy methods, such as photon-based radiotherapy, is its ability to penetrate only a few centimeters into tissue before losing energy. This characteristic makes it particularly suitable for treating tumors that are close to the surface of the body or in areas where greater precision is required.}\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -EBRT can be used to treat various types of cancer, including breast, lung, skin, and head and neck cancers. It may also be employed as a supplementary treatment alongside surgery or other therapies like chemotherapy. The overall effectiveness of EBRT depends on factors such as the patient's age, general health, tumor size, location, and response to previous treatments.}}} +The underlying mechanism behind FLASH radiotherapy is believed to involve the generation of reactive oxygen species (ROS) within tumor cells, which are more susceptible to damage from high doses of ionizing radiation than healthy tissues. The rapid delivery of these pulses allows for minimal ROS production in normal tissue, reducing the risk of side effects and enhancing treatment tolerance. } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Problems: short pulses + intenstiy / high dose -> resulting high dose rate make dose measurement difficult as different typical dosimetry technics show a deviation from the necessary linear detection efficiency. Including the primary standard of dose absorbed to water via Fricke dosimetry. Furthermore, for most standard medical accelerators these beam conditions are challenging to impossible to archive, requiring substantial improvement or the development of new dedicated FLASH accelerators. Additionally to the possibility to generate beams for FLASH RT also the diagnostic and simulation for these type of beams need to be adjusted and brought up to the high level necessary for clinical appllication\u8230\'85} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch FLASH}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203850184}\loch\sl240\slmult1\loch{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -FLASH Radiotherapy is a novel approach to cancer treatment that involves delivering very high doses of ionizing radiation in an ultra-short time frame, typically within milliseconds or less. This technique aims to exploit the unique properties of these short pulses to enhance tumor cell killing while minimizing damage to surrounding healthy tissues.}\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -The primary advantage of FLASH radiotherapy is its ability to achieve significantly higher doses than conventional radiation therapy without causing severe side effects, such as acute normal tissue reactions or long-term complications. This increased efficacy may lead to improved treatment outcomes and reduced overall toxicity for patients with various types of cancer.}\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -The underlying mechanism behind FLASH radiotherapy is believed to involve the generation of reactive oxygen species (ROS) within tumor cells, which are more susceptible to damage from high doses of ionizing radiation than healthy tissues. The rapid delivery of these pulses allows for minimal ROS production in normal tissue, reducing the risk of side effects and enhancing treatment tolerance.}\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -FLASH radiotherapy is still under investigation, with ongoing clinical trials assessing its safety and efficacy across different cancer types. If proven effective, this innovative approach could revolutionize radiation therapy by offering a more targeted and less toxic method for treating various forms of cancer.}}} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -MRT} +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203850184}\loch\lang1033\b0\sl240\slmult1\loch{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +FLASH Radiotherapy is a novel approach to cancer treatment that involves delivering very high doses of ionizing radiation in an ultra-short time frame, typically within milliseconds or less. This technique aims to exploit the unique properties of these short pulses to enhance tumor cell killing while minimizing damage to surrounding healthy tissues.}\par\loch\sl240\slmult1{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +The primary advantage of FLASH radiotherapy is its ability to achieve significantly higher doses than conventional radiation therapy without causing severe side effects, such as acute normal tissue reactions or long-term complications. This increased efficacy may lead to improved treatment outcomes and reduced overall toxicity for patients with various types of cancer.}\par\loch\sl240\slmult1{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +The underlying mechanism behind FLASH radiotherapy is believed to involve the generation of reactive oxygen species (ROS) within tumor cells, which are more susceptible to damage from high doses of ionizing radiation than healthy tissues. The rapid delivery of these pulses allows for minimal ROS production in normal tissue, reducing the risk of side effects and enhancing treatment tolerance.}\par\loch\sl240\slmult1{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}\par\loch\sl240\slmult1{\rtlch\af18\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +FLASH radiotherapy is still under investigation, with ongoing clinical trials assessing its safety and efficacy across different cancer types. If proven effective, this innovative approach could revolutionize radiation therapy by offering a more targeted and less toxic method for treating various forms of cancer.}}}{\loch\lang1033\b0\loch + auch offene punkte?/challanges dosimetry, accuary but also biologically }{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate -2017371354}\loch\lang1033\b0\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql\loch{\rtlch\alang1081\ai0\ab0\afs24\af18 \ltrch\langfe2052\lang1033\hich\af3\loch\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\fs20\f3\dbch\af20\langfe2052\loch + A prerequisite for systematically investigating the}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\fs20\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\dbch\langfe2052\af20\loch +biological effects of uHDR is a sound understanding and control of the challenging short-pulse}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\ai0\ab0\afs24\af18 \ltrch\langfe2052\lang1033\hich\af3\loch\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\fs20\f3\dbch\af20\langfe2052\loch +dynamics for ions, electrons, and photons. Short pulses and variable repetition rates down to}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\fs20\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\dbch\langfe2052\af20\loch +micro-beams and micro-structures in the GHz and THz range have to be delivered reliably and}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\ai0\ab0\afs24\af18 \ltrch\langfe2052\lang1033\hich\af3\loch\scaps0\caps0\accnone\cf0\lang1033\expnd0\expndtw0\kerning1\shad0\outl0\i0\strike0\ulnone\ulc0\b0\charscalex100\fs20\f3\dbch\af20\langfe2052\loch +reproducibly. This module deals with the experimental and theoretical prerequisites (non-}\par\loch\ltrpar\aspalpha\li0\ri0\lin0\rin0\fi0\sb0\sa0\sl240\slmult1\ql{\rtlch\alang1081\af18\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\fs20\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\dbch\langfe2052\af20\loch +equilibrium beam physics, instrumentation, control). H}}}{\loch\lang1033\b0\loch + } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 + }{\loch\lang1033\b0\loch +requirements on stability and metrology of the used beams not yet fulfilled} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +primary standard of standard particle RT not directly applicable} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +discrepancy observed between measured dose and simulated} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +non-linearity in detectors at ultra-high dose rates (e.g. high ion recombination rate)} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u8594\'3f }{\loch\lang1033\b0\loch +improved by UHDpulse project, still open questions} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +simulation of dose does in most cases do not consider interaction between beam particles} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +most diagnostic focuses on beam outside accelerator, potential of fast and accurate} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +accelerator diagnostic not fully exploited (e.g. shot by shot charge, position, size, ...} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +measurements)} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +optimal parameters such as pulse duration, intensity and energy not yet medically clear} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +input to possible parameter areas, that can be provided reliably by accelerators needed} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +new accelerator types (e.g. laser-based ones for higher energies) bring also different beam} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +dynamic effects to be considered, such as high energy spread, shot-to-shot variation, ...} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +, und MRT here erkl\u228\'e4ren } +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +auch offene punkte} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Spatially structured RT} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +Microbeam RT mainly studied with x-rays but similar potential for particle beams as} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +demonstrated with GRID therapy} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +modulation done mostly close to target} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +spatially modulated beams (non-Gaussian dose distribution) relevant to accommodate} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +either irregular/uneven patient surfaces (e.g. electron conformal therapy ECT) or achieve} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +homogeneous dose distributions} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +mostly handled by scanning, masks/collimators or bolus ECT} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +General} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +no interaction between beam particles considered in most simulations (e.g. FLUKA,} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +EGSnrc, BDSIM with Geant4)} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u9654\'3f }{\loch\lang1033\b0\loch +OPAL does include 3D space charge, seems to mainly be used for proton therapy} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0 +\u8658\'3f }{\loch\lang1033\b0\loch +Little to no mentioning of consideration of collective effects, which (from accelerator physics} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +point of view) is expected to play an increasing role with decreasing pulse length and increasing} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +pulse intensity, as well as with spatial structuring of the beam.} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +Dann daraus basierend offene anforderungen an accelerator knowledge} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch +complex dynamics, collective effects, but also diagnostics for ?quality assurance?} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Accelerator, Linac} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch @@ -596,12 +838,6 @@ collective effects, space charge\u8230\'85} explanation } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -- radio therapy is an important tool in cancer therapy} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -- continuous development towards improved tolerability and increase of the therapeutic} -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -window} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch - two promising developments in recent years:} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch @@ -937,71 +1173,73 @@ diagnostic problem, durch kurz strahl pulse} \par \pard\plain \s2\rtlch\af16\afs20\alang1025\ai\ab \ltrch\lang1033\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tx576\hyphpar0\faauto\li576\ri0\lin576\rin0\fi-576\keepn\ltrpar\cf0\f5\fs22\lang1033\b\kerning1\dbch\af12\langfe1031{\listtext\pard\plain \rtlch\af13 \ltrch\hich\af5\loch\f5\fs20\i0\b 2.4\tab}\ilvl1\ls1 \li1152\ri0\lin1152\rin0\fi-576\sl288\slmult1\tx576{\loch Handling of research data}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203835956}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -. We will follow Open Science principles, generate}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203835956}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +. We will follow Open Science principles, generate}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch FAIR (Findable, Accessible, Interoperable, Reusable) data,}}} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\b0\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\loch\lang1033\b0\loch -The research data produced in this project will cover a wide variety of data types, sizes and formats. Measurement data will originate from the multitude of accelerator beam diagnostic system such as charge measurement, beam position information, transversal bunch profiles monitors or gun laser parameters}{\loch\cf20\lang1033\b0\loch -, as well as from dose measurements in the water phantom. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +The research data produced in this project will cover a wide variety of data types, sizes and formats. Measurement data will originate from the multitude of accelerator beam diagnostic system such as charge measurement, beam position information, transversal bunch profiles monitors or gun laser parameter}{\rtlch\ab0 \ltrch\lang1033\loch\lang1033\b0\loch +s, as well as from dose measurements in the water phantom.}{\loch\cf20\lang1033\b0\loch + }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Estimating the total amount of measurement data to be generated over the course of the 6 year project duration results in several TBytes due to the multitude of diagnostics continuously running during the accelerator experiments combined with systematic parameter scans including imaging data from 2D profile measurements. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Simulation will be conducted with multiple existing simulation tools like EGSnrc, FLUKA, ASTRA or Ocelott (add citation!). Furthermore, results from theoretical calculations such as self implemented simulation tools are expected and will contribute to the resulting research data as well as the developed software tools themselves. Due to the use of particle tracking simulation tools and the possibility to run}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708789}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708789}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch Have experience with HPC for running simulations}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch simulations on a HPC cluster}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708788}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708788}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch HoreKa, mention here?}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch , the estimated amount of simulation data is also in the range of several TBytes. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708790}\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -Not mentioned until now: post processing&analyzing (extract specific parameters, like a value for bunch size from screen recording, FFT,... plotting...)? Systematic comparison for parameter scan and with simulated values? - most will be done in python (much experience), matlab and what ever the used simulation tools are programmed in}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -programming languages including python, matlab, \uc3 \u8230\'e2\'80\'a6.\uc1 }\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708790}\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +Not mentioned until now: post processing&analyzing (extract specific parameters, like a value for bunch size from screen recording, FFT,... plotting...)? Systematic comparison for parameter scan and with simulated values? - most will be done in python (much experience), matlab and what ever the used simulation tools are programmed in}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +programming languages including python, matlab, \uc3 \u8230\'e2\'80\'a6.\uc1 }\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch size/data volume?? approx 10 TByte in sum?}}}{\loch\lang1033\b0\loch The file formats will depend on the diagnostic systems or simulation tools and can range from for example TXT, PNG, JSON or CSV to proprietary file formats such as MAT (Matlab) or custom binary file-formats. If the original format is not easily accessible and/or additional metadata should be saved with the original data, the data will be transferred into files of the hdf5 file-format (Hierarchical Data Format version 5).}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708586}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -@online\{hdf5,}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -author = \{\{The HDF Group\}\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -date-added = \{2019-10-29 20:36:49 +0100\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -date-modified = \{2019-10-29 21:07:12 +0100\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -title = \{\{Hierarchical Data Format, version 5\}\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -url = \{https://www.hdfgroup.org/HDF5/\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -year = \{1997-2019\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708586}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +@online\{hdf5,}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +author = \{\{The HDF Group\}\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +date-added = \{2019-10-29 20:36:49 +0100\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +date-modified = \{2019-10-29 21:07:12 +0100\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +title = \{\{Hierarchical Data Format, version 5\}\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +url = \{https://www.hdfgroup.org/HDF5/\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +year = \{1997-2019\},}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch bdsk-url-1 = \{https://www.hdfgroup.org/HDF5/\}\}}}}{\loch\lang1033\b0\loch - In the past,}{\loch\cf20\lang1033\b0\loch - the applicant has/ I have ???used }{\loch\lang1033\b0\loch + In}{\rtlch\ab0 \ltrch\lang1033\loch\lang1033\b0\loch + the past, I have used }{\loch\lang1033\b0\loch the hdf5 file-format extensively and it has proven to be very useful to store complex data, as it is accessible with a wide variety of programming languages (e.g. Python, Matlab, C++) and provides the possibility for internal structuring the stored data in groups, multi-dimensional datasets and amend each substructure with attributes. This allows the collection of connected data, such as the output of different diagnostic tools during one experiment, as well as the addition of metadata. In this way all the information from different sources needed to evaluate measurement results including information about the used instrument types, configuration and settings and furthermore operational parameters of the accelerator. The same principle can be applied to data resulting from calculations and simulations. In this case, it is possible to for example save different derived properties of the simulation output additionally to the simulation results or combine output given in multiple files into one. And furthermore, to keep the context of the simulation and improve the re-usability, all the simulation input parameters and settings can be stored as metadata in the attributes of the hdf5-files. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Also in cases, where the stored data is not in SI units conversion factors can be included in the metadata}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708681}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708681}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch Reference to Inovesa??}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch . }{\loch\lang1033\b0\loch In cases where the read-out software or the simulation tool will be programmed from scratch, the hdf5 file-format will be used directly. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch A consistent filename convention will be implemented including the date (in the human readable date format ISO8601), a short name for the detector respective the simulation tool, and further information. Additional information relevant for later analysis or re-use of the data will be, as mentioned earlier, saved as metadata, either live during the measurement, for example, by reading accelerator parameters provided online from the accelerator control-system (EPICS) (always including Unix timestamps for each added parameter) or, alternatively, added later on in post-processing. All relevant accelerator settings, parameters or properties are by design saved continuously in a Casandra database. A corresponding post-processing workflow can be based on an existing Python framework}{\rtlch\afs28 \ltrch\lang1033\loch\cf20\lang1033\b0\loch - developed by the applicant/me?? which was successfully used to process more than 50 TByte of measurement data during the PhD studies. } + }{\rtlch\ab0 \ltrch\lang1033\loch\lang1033\b0\loch +developed by me which was successfully used to process more than 50 TByte of measurement data during my PhD studies. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch To document the conducted experiments, the digital logbook ELOG }{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708911}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708911}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://elog.psi.ch/elog/}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch will be used. Originally developed at the Paul Scherrer Institut (Switzerland) under the GNU Public License, it is used in multiple accelerator facilities as a documentation standard. Small data files can be directly linked to the corresponding entries. Larger files will be stored in structured directories on a file server of the institute and a link to the storage location will be added to the ELOG entry. For documentations exceeding the logging during individual measurements, an instance of a wiki is available at the institute. Sub-spaces for individual teams can be created with corresponding access rights. There, information or discussions regarding multiple measurements or simulations can be stored. Within the framework of scientific research, regular comparisons between simulated and measured data will be performed to ensure consistency and increase data quality. Furthermore regular reference measurements at well known conditions are performed to characterize the detection chains. Regular meetings and discussions on the acquired data will be held to minimize human bias (four eyes principle). For the development of software a GitLab}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708944}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708944}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://about.gitlab.com/}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch instance will be used. This provides a version controlled and simple possibility to save, transfer and jointly work on source codes. With the usage of GIT}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708942}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708942}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://git-scm.com/}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch (distributed version control system), there is also the possibility to implement basic quality control mechanisms, e.g. git hook frameworks like pre-commit}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708941}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1740708941}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://pre-commit.com/}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch , which check the integrity of the source code before committing. For all python scripts the PEP8 coding-style convention will be respected. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -For immediate storage during the runtime of the project, the data will be saved on the institute\u8217\'92s own servers which are equipped with backups and allow to manage the access rights via user-groups. A specific group directory would be created with a systematic folder structure to allow the storage of the generated measurement and simulation data sorted by type and date. In addition to ensure minimal data loss every personal pc of group members will be equipped with an external backup harddrive and each member will be instructed to perform regular backups.} +For immediate storage during the runtime of the project, the data will be saved on the institute\u8217\'92s own servers which are equipped with backups and allow to manage the access rights via user-groups. A specific group directory would be created with a systematic folder structure to allow the storage of the generated measurement and simulation data sorted by type and date. In addition to ensure minimal data loss every personal pc of group members will be equipped with an external backup hard drive and each member will be instructed to perform regular backups.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch For long-term storage and archival of data the multi-petabyte storage systems of the host institution (e.g. LSDF) including the archival on tape storage will be used. A minimum storage period of 10 years is default for these services. Those are provided by the host institution at no cost. In addition, RADAR4KIT, a research data repository, can be used to, to bundle data and metadata, store and archive this data with the possibility to provide public access later on. For publications, high-level derivative data can be added as supplementary material on the journal web-page. For simulation data, produced with publicly available simulation code, the minimal set of parameters to recreate the simulations will be added. The corresponding full data sets can be published in KITopen via RADAR4KIT, receive a DOI and is open access. Software developed in the framework of this project is planned to be open-source and published on services such as GitHub.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Members of the project group will be provided with the possibility to learn the usage of technologies regarding data management used for the project. Due to the continuous availability throughout the project and previous experiences with large data and software management, the applicant will take on the task of coordinating the handling of research data for the project supported by the IT team of the host institute. Since the usage of established storage solutions is foreseen, the long-term storage and archival responsibility after the project ends lies with KIT.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Research data management within the project as well as the used services will conform to the guidelines published by KIT (\u8220\'93Guidelines for Responsible and Sustainable Research Data Management at KIT (RDM Policy)\u8221\'94) as well as the DFG code of conduct, and the EU open science policy.}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203835785}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203835785}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://www.rdm.kit.edu/english/researchdata_policies_kit.php}}} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch @@ -1033,30 +1271,30 @@ Please justify the choice of each proposed host institution.} The Karlsruhe Institute of Technology (KIT) would provide an exceptionally well-suited research environment with an unique combination of multidisciplinary research infrastructure and strategic collaborations within the multitude of institutes in complementary research fields as well as with external institutions. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch The KIT is one of the eleven \u8220\'93Universities of Excellence\u8221\'94 in Germany. It is unique in that it combines a university and a national research laboratory (in the Helmholtz Association) within one entity resulting in one of the biggest science institutions in Europe. These conditions provide the opportunity to combine academic and fundamental research with application-based and goal-oriented research. KIT offers the possibility to profit from the motivation and ingenuity of students and early-carrier researchers and at the same time gives access to large-scale research facilities. }{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963186}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963186}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch AUCH M\uc2 \u214\'c3\'96GLICHKEIT ZU LEHRE- also 100 new professorships going to be established\uc3 \u8230\'e2\'80\'a6.?\uc1 }}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch The excellent research at KIT covers among others the disciplines of natural and engineering sciences. Interdisciplinary KIT Centers bring together scientists from different institutes to cross-divisionally tackle challenges and research actives connected to the further development and technological improvement of society. This quest naturally leaves KIT striving to push also the advancement of medical technologies. As newest of the nine KIT Centers, the Center \u8220\'93Health Technologies\u8221\'94}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963214}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963214}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch \uc3 \u8220\'e2\'80\'9cThe KIT Center \u8222\'e2\'80\'9eHealth Technologies\u8220\'e2\'80\'9c promotes the digital transformation of medical technologies, humanoid robotics, personalized medicine and health care to provide next generation innovation for the global health challenges of today and tomorrow.\u8221\'e2\'80\'9d\uc1 }}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch has recently been established in March 2023 aiming to \u8220\'93provide next generation innovation for the global health challenges of today and tomorrow\u8221\'94}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963220}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963220}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://www.healthtech.kit.edu/index.php}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch .}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963186}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963186}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch ...WAS hilft das? Health related research environment..}}} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Another piece of the puzzle is the research bridge \u8220\'93Medical Technology for Health (MTH)\u8221\'94 with the aim to combine knowledge from engineering sciences, molecular basic research and bio-informatics with medical expertise to develop better diagnostics and therapy. The bridge is part of the longstanding strategic partnership with the Heidelberg University HEIKA (Heidelberg Karlsruhe Strategic Partnership)}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963231}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963231}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch (close connection provides access to Heidelberg research?? also HIT???)}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch which was initiated in order to combine the complementary competencies of the two Universities. Furthermore, a joint master program in medical engineering in cooperation with the University Heidelberg is planned to start in the winter semester 24/25}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963266}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963266}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch https://www.kit.edu/kit/english/pi_2022_051_new-medical-engineering-study-program-to-bridge-gap-between-people-and-technology.php}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch . } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch - Hilft weil bringt die medicine componente mit rein...}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963242}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch --(CHECK OUT: Prof. Dr. Dr. J\uc2 \u252\'c3\'bcrgen Debus / Prof. Dr. Ivan Peri\uc1 }{\rtlch\alang1081\ai0\ab0\af20\afs28 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -\uc2 \u263\'c4\'87\uc1 }{\rtlch\alang1081\ai0\ab0\af18\afs24 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963242}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +-(CHECK OUT: Prof. Dr. Dr. J\uc2 \u252\'c3\'bcrgen Debus / Prof. Dr. Ivan Peri\uc1 }{\rtlch\alang1081\ai0\ab0\af21\afs28 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +\uc2 \u263\'c4\'87\uc1 }{\rtlch\alang1081\ai0\ab0\af18\afs24 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch Particle therapy beam monitoring with HV-CMOS sensors)}}} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch - aufbruchstimmung gut um eine gruppe and der schnittstelle zwischen beschleuiniger und eben medizinischer technology zu etablieren und bietet viele wachstums m\u246\'f6glichkeiten im sinne von Kollaborationen mit instituten und experten au\u223\'dferhalb des eigenen forschungsfeldet \u8230\'85.} @@ -1070,41 +1308,40 @@ https://www.kit.edu/kit/english/pi_2022_051_new-medical-engineering-study-progra \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch The Accelerator Technology Platform (ATP) at KIT combines KIT internal expertise and infrastructures relevant for accelerator research, development and application. This not only includes the KIT based accelerators FLUTE and KARA (see below), experts in accelerator physics (IBPT) and accelerator relevant technologies like the Magnet Characterization Facilities (MCF) and cryogenic research laboratories, but furthermore it also includes experts and infrastructure on advanced detector technologies studying for example ultra-fast and radiation hard detection systems.}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963236}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -\uc3 \u8230\'e2\'80\'a6..WAS bringt es mir\uc1 }\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -(check on: dosimetry, neutron detection}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -and simulation of particle transport (R. Stieglitz, R. Engel, A. Ferrari), und auch mathematical models for dose calculations and RT treatment planning and simulation of}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963236}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +\uc3 \u8230\'e2\'80\'a6..WAS bringt es mir\uc1 }\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +(check on: dosimetry, neutron detection}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +and simulation of particle transport (R. Stieglitz, R. Engel, A. Ferrari), und auch mathematical models for dose calculations and RT treatment planning and simulation of}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch oxygenation in tumor tissue (M. Frank))}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + }{ +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666962739}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +Kann das drin sein? Nein!}\par\loch\sl240\slmult1{\rtlch\ab0\ai0\alang1081\afs24\af18 \ltrch\lang1033\langfe2052\hich\af3\loch\lang1033\b0\ulnone\ulc0\strike0\shad0\charscalex100\i0\kerning0\fs20\f3\accnone\outl0\cf1\expnd0\expndtw0\scaps0\caps0\dbch\langfe2052\af21\loch +All the above is planned to serve as a foundation for a new Cluster of Excellence called AccelerateRT, aiming for basic research towards a more effective, efficient and widely available radiotherapy by focusing on tailored compact accelerators, corresponding beam control, dosimetry and visualization and the resulting bio-medical effects of novel radiotherapy qualities. }\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\langfe2052\lang1033\hich\af3\loch\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\kerning0\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\langfe2052\af21\loch +(We plan to build the scientific foundations of a new generation of}\par\loch\sl240\slmult1{\rtlch\ab0\af18\afs24\ai0\alang1081 \ltrch\lang1033\langfe2052\hich\af3\loch\cf1\f3\outl0\kerning0\expnd0\expndtw0\lang1033\ulnone\ulc0\accnone\fs20\strike0\scaps0\caps0\charscalex100\b0\i0\shad0\dbch\langfe2052\af21\loch +radiotherapy with the goal to substantially improve cancer cure rates. Our long-term vision is}\par\loch\sl240\slmult1{\rtlch\ab0\af18\afs24\ai0\alang1081 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\outl0\cf1\shad0\lang1033\charscalex100\accnone\b0\scaps0\caps0\f3\fs20\ulnone\ulc0\strike0\i0\expnd0\expndtw0\dbch\langfe2052\af21\loch +to translate this basic research into more effective, efficient and widely available radiotherapy.}\par\loch\sl240\slmult1{\rtlch\ab0\af18\afs24\ai0\alang1081 \ltrch\lang1033\langfe2052\hich\af3\loch\cf1\f3\outl0\kerning0\expnd0\expndtw0\lang1033\ulnone\ulc0\accnone\fs20\strike0\scaps0\caps0\charscalex100\b0\i0\shad0\dbch\langfe2052\af21\loch +The basic research in AccelerateRT will focus on three major areas: (A) tailored compact}\par\loch\sl240\slmult1{\rtlch\ab0\af18\afs24\ai0\alang1081 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\outl0\cf1\shad0\lang1033\charscalex100\accnone\b0\scaps0\caps0\f3\fs20\ulnone\ulc0\strike0\i0\expnd0\expndtw0\dbch\langfe2052\af21\loch +accelerators, (B) beam control, dosimetry and visualization of irradiation efficacy, and}\par\loch\sl240\slmult1{\rtlch\ab0\af18\afs24\ai0\alang1081 \ltrch\lang1033\langfe2052\hich\af3\loch\cf1\f3\outl0\kerning0\expnd0\expndtw0\lang1033\ulnone\ulc0\accnone\fs20\strike0\scaps0\caps0\charscalex100\b0\i0\shad0\dbch\langfe2052\af21\loch +(C) exploration of bio-medical effects and optimization of novel radiotherapy qualities. )}\par\loch\sl240\slmult1{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}}}{\loch } -\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666962739}\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -Kann das drin sein?}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -All the above is planned to serve as a foundation for a new Cluster of Excellence called AccelerateRT, aiming for basic research towards a more effective, efficient and widely available radiotherapy }{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666962726}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -We plan to build the scientific foundations of a new generation of}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -radiotherapy with the goal to substantially improve cancer cure rates. Our long-term vision is}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -to translate this basic research into more effective, efficient and widely available radiotherapy.}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -The basic research in AccelerateRT will focus on three major areas: (A) tailored compact}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -accelerators, (B) beam control, dosimetry and visualization of irradiation efficacy, and}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -(C) exploration of bio-medical effects and optimization of novel radiotherapy qualities. }}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch -by focusing on tailored compact accelerators, corresponding beam control, dosimetry and visualization and the resulting bio-medical effects of novel radiotherapy qualities.} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch With the experimental part of the proposed project relying on the possibility to conduct systematic measurement on accelerators and beams, KIT with the Institute for Beam Physics and Technology (IBPT) is an ideal environment in that it provides easy and extended access for in-house researchers to its electron accelerators. Both accelerators serve as accelerator test facilities for a variety of accelerator physics studies, leading to a high flexibility in available operation modes and beam conditions and the possibility to tailor operation modes to experimental requirements. To this end the accelerators are equipped with extensive, state of the art diagnostics and continuously serve as a test-bed for research towards novel and improved diagnostic methods. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch The 2.5 GeV storage ring and synchrotron light source KARA}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963016}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963016}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch The research infrastructure (RI) Karlsruhe Research Accelerator (KARA) provides a 2.5-GeV storage ring and light source for experiments with electron beams and intense electromagnetic, synchrotron radiation for deep insights into matter, in biological structures and materials. KARA as a test facility, together with other RIs within the Accelerator Technology Platform (ATP) at KIT support R&D of technologies for tomorrow's accelerators and detectors. This covers a broad method spectrum from superconducting magnet technology, simulation and modelling, novel diagnostics, via ultra-fast detectors and readout electronics, digitization, AI incl. machine learning, robotics, to laser-based accelerators. Jointly, scientists from KARA and Energy Lab 2.0 address global challenges in the area of energy, fostering novel concepts for current and future RIs focusing on sustainable energy solutions from components to systems. KARA is operated and developed by IBPT and also in use in research-oriented teaching and for innovation.}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch (Karlsruhe Research Accelerator) is based on the ANKA (Angstr\u246\'f6mquelle Karlsruhe) which started operation in 2003 and which has been improved continuously since then. KARA provides short-pulsed x-ray modalities at multiple beam lines. Further more, }{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963008}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963008}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch Neue powersupplies daher bessere stabilit\uc2 \u228\'c3\'a4t im kurz pulse betrieb, aber paper noch nicht published, erst bei IPAC.\uc1 }}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch additional operation modes have been implemented at different electron energies such as for example a short-pulse operation allowing the investigation of the dynamics in short electron bunches [Quelle mit mir?] as well as the development and tests of novel, fast diagnostic methods [auch Quelle mit mir?]. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch The second accelerator at KIT-IBPT is the linear electron accelerator FLUTE (Ferninfrarot Linac- und Test-Experiment)}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666962741}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch -The new FLUTE facilitiy (name abbreviation derived from its German name: Ferninfrarot Linac- und Test-Experiment) at the Karlsruhe Institute of Technology (KIT), developed and operated by IBPT, serves as an accelerator test facility for a variety of accelerator physics studies.}\par\loch\sl240\slmult1{\rtlch\alang1023\af22 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af21\loch -}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666962741}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch +The new FLUTE facilitiy (name abbreviation derived from its German name: Ferninfrarot Linac- und Test-Experiment) at the Karlsruhe Institute of Technology (KIT), developed and operated by IBPT, serves as an accelerator test facility for a variety of accelerator physics studies.}\par\loch\sl240\slmult1{\rtlch\alang1023\af23 \ltrch\lang1023\langfe1023\hich\af3\loch\f3\fs24\b0\kerning0\lang1023\dbch\langfe1023\af22\loch +}\par\loch\sl240\slmult1{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch The core accelerator consists of a femtosecond chirped laser-driven photo-injector, a linear accelerator (linac) and an electron bunch compressor to provide ultra-short electron bunches. This compact versatile linear accelerator will also provide coherent radiation in ultra-short, very intense, light pulses spanning the terahertz and far-infrared spectral range and beyond. FLUTE also provides an infrastruture for picosecond and femtosecond electron and photon beam studies to enable future application-oriented research from materials to life sciences and innovative technology solutions such as advanced electron and photon beam diagnostics.}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch . It is designed to provide ultra-short electron pulses with an energy of around 6 MeV after the low-energy section and with energies of up to 50 MeV and bunch lengths down to femtoseconds after the full accelerator. Furthermore, FLUTE provides coherent radiation in ultra-short, very intense light pulses from terahertz to far-infrared and beyond. The electrons pulses in FLUTE are generated with a femtosecond chirped laser-driven photo-injector. Recent studies include the application of machine learning for accelerator tuning tasks based on reinforcement learning as well as extend the existing diagnostics with virtual diagnostics achieved by surrogate modeling of the electron beam dynamics. Also of great importance is the recent implementation of a spatial light-modulator which allows spatial and temporal shaping of the laser pulse on the photo-cathode and therefore control of the initial electron distribution in the accelerator. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch @@ -1117,7 +1354,7 @@ PERFECT FOR INVESTIGATIONS OF FLASH LIKE RT BEAM MODALITIES...} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch Besides the two existing accelerators, two more are planned to be build within the near future. A 50 MeV laser-plasma accelerator is being build as part of the ATHENA project}{ -{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963153}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af20\langfe2052\loch +{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 666963153}\loch\sl240\slmult1\loch{\rtlch\af18\afs24\alang1081\ai0\ab0 \ltrch\lang1033\langfe2052\hich\af3\loch\kerning0\scaps0\caps0\expnd0\expndtw0\cf1\outl0\accnone\f3\fs20\lang1033\i0\charscalex100\shad0\strike0\ulnone\ulc0\b0\dbch\af21\langfe2052\loch ATHENA, https://www.athena-helmholtz.de/home/index_eng.html, May 2022.}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch in collaboration with DESY and the Helmholtz Institute Jena (HIJ). This will open the opportunity to test the developed simulation and diagnostic methods to a different type of accelerator and investigate the possibilities and limitations of LPA beams for radiotherapy. Last but not least, an innovative non-equilibrium storage ring with a wide energy acceptance will be build and will be able to accept both, the LPA as well as FLUTE, as injector. Storing the sub-picosecond to femtosecond short beams will lead to continuous electron bunch lengthening over the revolutions and will provide the possibility to study the effects of different pulse lengths on the detected dosage. } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch @@ -1130,6 +1367,16 @@ Even tough alma mater \u8211\'96 unparalleled opportunities, due to unique envir Strong advantage as provides accelerator based high-intensity x-ray beams as well as ultra-short pulse electron beams at the same institution\u8230\'85..} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch perfect fit for experimental part, and due to many existing centers, clusters, and collaborations great, nurturing environment also for multi-disciplinary input and solutions.} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch + +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +Embedded in one of Germany\u8217\'92s leading healthcare and technology regions, }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +(}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +AccelerateRT}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +)}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch + is} +\par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch +especially well positioned to\u8230\'85...} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch \par \pard\plain \s1\rtlch\af13\afs24\alang1025\ab \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tx432\hyphpar0\faauto\li432\ri0\lin432\rin0\fi-432\keepn\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031{\listtext\pard\plain \rtlch\af13 \ltrch\loch\fs22\i0\b 3\tab}\ilvl0\ls1 \li864\ri0\lin864\rin0\fi-432\sl288\slmult1\tx432{\loch\lang1033\loch @@ -1229,7 +1476,14 @@ Researchers in Germany with whom you have agreed to cooperate on this project} \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\highlight7\loch \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch -[Text] Oliver J\u228\'e4kel Heidelberg, Anke, Husemann?} +[Text] Oliver J\u228\'e4kel }{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +(}{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +Heidelberg}{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +)}{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +, Anke, }{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +Erik, }{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch +Lennart Volz?, }{\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\loch + } \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang2057\loch\lang2057\b0\highlight7\loch \par \pard\plain \s2\rtlch\af16\afs20\alang1025\ai\ab \ltrch\lang1033\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tx576\hyphpar0\faauto\li576\ri0\lin576\rin0\fi-576\keepn\ltrpar\cf0\f5\fs22\lang1033\b\kerning1\dbch\af12\langfe1031{\listtext\pard\plain \rtlch\af13 \ltrch\hich\af5\loch\f5\fs20\i0\b 4.5\tab}\ilvl1\ls1 \li1152\ri0\lin1152\rin0\fi-576\sl288\slmult1\tx576{\loch @@ -1314,7 +1568,7 @@ Please use this section for any additional information 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\ltrch\lang1033\loch\lang1033\b0\loch \par \pard\plain \s1\rtlch\af13\afs24\alang1025\ab \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\tx432\hyphpar0\faauto\li432\ri0\lin432\rin0\fi-432\keepn\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031{\listtext\pard\plain \rtlch\af13 \ltrch\loch\fs22\i0\b 5\tab}\ilvl0\ls1 \li864\ri0\lin864\rin0\fi-432\sl288\slmult1\tx432{\loch\lang1033\loch @@ -1338,7 +1592,7 @@ Clinician scientists may apply for a temporary substitute position instead of a \par \pard\plain \s0\rtlch\af13\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af12\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\lang1033\b0\loch \par \pard\plain \s2\rtlch\af16\afs20\alang1025\ai\ab 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