dump

emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf#

@@ -1 +1 @@
-,mirbro,w-mirbro-pc-0,15.01.2024 18:33,file:///home/mirbro/.config/libreoffice/4;
+,mirbro,w-mirbro-pc-0,16.01.2024 23:55,file:///home/mirbro/.config/libreoffice/4;

emmy_noether/53_05_en_elan_projectdescription_draft.rtf

@@ -514,6 +514,16 @@
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@@ -12971,12 +12981,15 @@ Objectives}
 The present advances in accelerator based RT, like FLASH RT or Microbeam RT, lead to operation parameters of the used accelerators that can not anymore be described by simple linear optics and beam dynamics. Instead, due to the development towards higher intensity combined with shorter pulse lengths and transverse modulations, the consideration o}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 f }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 non-linear and complex beam dynamics influenced by collective effects becomes necessary for accelerator RT sources. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-Not only in the accelerator but also for the diagnostics and dosimetry as well as for the beam matter interaction on the way to the target the effect of these extreme pulse parameters need to be systematically investigated. Further bringing together}{
+Not only in the accelerator but also for the diagnostics and dosimetry as well as for the beam matter interaction on the way to the target the effect of these extreme pulse }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+properties}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+ need to be systematically investigated. Further bringing together}{
 {\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 130118971}\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\li0\ri0\lin0\rin0\fi0\sl240\slmult1\loch{\rtlch\alang1081\af19\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af21\loch
  closing the gap between}\par\loch\li0\ri0\lin0\rin0\fi0\sl240\slmult1{\rtlch\alang1081\af19\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af21\loch
 intertwining}}}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
  accelerator science and medical physics }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-in this project}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+through}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+ this project}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
  is an important step and will }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 help }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 in paving the way towards accurate }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
@@ -12992,6 +13005,14 @@ beams}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
  }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 based on}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
  particle accelerators.}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\tx576\li0\ri0\lin0\rin0\fi0\loch
+
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
+s}{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
+patially structured, challenge in dosimetry, short pulses change everything, from biological interaction with tissue which is the main advantage but also in dosimetry, and for generation and diagnostic in accelerators}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\tx576\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
+and investigate how it affects the production, propagation and detection/diagnostic of such beams and how its inclusion into theoretical calculation and simulations can contribute to bringing these new RT modalities with more extreme beam parameters closer to clinical application. }
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
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@@ -24460,23 +24481,49 @@ arbeits}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 punkte. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 So wie in karte darfgestellt sind sie verkn\u252\'fcpft mit den meisten wichtigen punkten\u8230\'85}
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-- improve prediction }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+- improve prediction by considering and incorporate self interaction/collective effect .., and test possible diagnostic and their dependence on parameters,\u8230\'85., test limitations of accelerator based beam modulation?}
-by considering and incorporate self interaction/collective effect }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-.., and }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+
-test possible}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
- diagnostic }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+The main objective is to }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-and their dependence on parameters}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+investigate how and which collective effects }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-,\u8230\'85., }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+(??}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-test limitations of }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+known in the accelerator beam }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-accelerator based beam modulation?}
+dynamics??}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+)}{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+ affect the beam transport, beam-matter interaction and diagnostics in novel electron radiotherapy methods with temporally and spatially structured beams. }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+For this the following sub-objectives are conceived/targeted?. }
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u8226\'95\tab}\ilvl0\ls6 \li720\ri0\lin720\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+improve predictability of RT beam properties and deposited dose on target}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+improve understanding of dynamic in generation of short or spatially structured RT beams}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+investigate accelerator diagnostics that will be beneficial in new medical accelerators}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+improve simulation of beam transport through matter by including collective effects}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+contribute to development of improved dosimetry detectors by testing at variety of beam conditions}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u8226\'95\tab}\ilvl0\ls6 \li720\ri0\lin720\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+characterize possibility to generate different temporal and spatial distributions on target already during beam generation}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u8226\'95\tab}\ilvl0\ls6 \li720\ri0\lin720\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+provide start-to-end simulations of RT beams, from inside the accelerator through the air into the target by combining beam dynamics, beam-matter interaction and collective effects simulations}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+first step: direct prediction of the resulting temporal&spatial distribution on target}{
+{\*\atnid }{\*\atnauthor Unknown Author}\chatn{\*\annotation{\*\atndate 1203865072}\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\li0\ri0\lin0\rin0\fi0\sl240\slmult1\loch{\rtlch\alang1081\af19\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af21\loch
+- predicting the temporal and spatial shape of each individual RT pulse at any point on the}\par\loch\li0\ri0\lin0\rin0\fi0\sl240\slmult1{\rtlch\alang1081\af19\afs24\ab0\ai0 \ltrch\lang1033\langfe2052\hich\af3\loch\cf0\f3\charscalex100\b0\ulnone\ulc0\strike0\i0\outl0\shad0\kerning1\expnd0\expndtw0\lang1033\accnone\scaps0\caps0\fs20\dbch\langfe2052\af21\loch
+way up to the target inside the patient}}}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+second step: consider deformation in beam transport already during the beam generation}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u9702\'3f\tab}\ilvl1\ls6 \li1080\ri0\lin1080\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+aiming towards the generation of a spatial distribution which preemptively compensates for the expected changes, possibly allowing arbitrary user-definable final distributions}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u8226\'95\tab}\ilvl0\ls6 \li720\ri0\lin720\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+systematically test effect of pulse properties on diagnostics and dosimetry dependent on length, size, shape, intensity/doserate}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031{\listtext\pard\plain \rtlch\af12 \ltrch\hich\af12\loch\f12\dbch\af12 \u8226\'95\tab}\ilvl0\ls6 \li720\ri0\lin720\rin0\fi-360\sl288\slmult1{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
+study from accelerator point of view the diagnostic to reliably deliver the requested conditions}
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\cf29\loch
 
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
-s}{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
+
-patially structured, challenge in dosimetry, short pulses change everything, from biological interaction with tissue which is the main advantage but also in dosimetry, and for generation and diagnostic in accelerators}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0
- }{\rtlch\afs28 \ltrch\lang1033\loch\cf29\lang1033\b0\loch
-and investigate how it affects the production, propagation and detection/diagnostic of such beams and how its inclusion into theoretical calculation and simulations can contribute to bringing these new RT modalities with more extreme beam parameters closer to clinical application. }
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\cf26\loch
 
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\alang1025 \ltrch\lang1033\langfe1031\loch\cf26\lang1033\b0\dbch\langfe1031\loch
@@ -24509,29 +24556,6 @@ new accelerator types (e.g. laser-based ones for higher energies) bring also dif
 dynamic effects to be considered, such as high energy spread, shot-to-shot variation, ...}
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\qj\li0\ri0\lin0\rin0\fi0\loch
 
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-Goals: \u8594\'3f }{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-Objectives! }
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-- improve predictability of RT beam properties on target by improving understanding of}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-dynamic in short and/or spatially structured RT beams (!!!spatially structured can be microbeams but also just not round/gaussian beams but more like flat, or narrow, or double peaked, any structure actually that can survive the path through accelerator/be formed at the end of accelerator!!)}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-- study from accelerator point of view the beam dynamics effects relevant in the generation}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-of such beams as well as the diagnostic to reliably deliver the requested conditions}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-- provide start-to-end simulations of the dynamic of RT beams, from inside the accelerator}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-through the air into the target by combining beam dynamics, beam-matter interaction and}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-collective effects simulations}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-- predicting the temporal and spatial shape of each individual RT pulse at any point on the}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
-way up to the target inside the patient}
-\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch
-
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
 The goal is, by extending the calculation of these effects beyond the accelerator as a first step,}
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch
@@ -24578,7 +24602,44 @@ with the experimental and theoretical prerequisites (non-equilibrium beam physic
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\cf22\loch
 
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
-the main aim is for improvements towards RT, but on the way there we will learn so much more, that will be helpful for many different application and research, such as even further increasing understanding of collective effects in acc. Influence of short but high intensity pulses on detectors\u8230\'85 possibility to modulate acc beams could be interesting for LPA or drivers of FELs\u8230\'85...}
+While }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+the main aim is for improvements towards RT, }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+the conducted research on }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+the way there }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+will generate new insights and understanding}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+, that will be }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+valuable}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+beyond the main topics for }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ different application}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+s}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ and research }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+areas. }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+The project will}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+improve the fundamental knowledge}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ of collective effects in }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+particle accelerators\u8230\'85..}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+The challenge }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+of measuring the power in short, high intensity pulses is not solely limited to dosimetry???/RT. }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+Systematic studies of the i}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+nfluence of }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+pulse length and intensity density could...}
+\par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+And furthermore the investigation of the }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+possibility to modulate }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+accelerator}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ beams could be }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+of interesst}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+for research into modulated }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+drive beams for}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+laser-plasma accelerators}{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+ }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+and }{\rtlch\afs28 \ltrch\lang1033\loch\cf22\lang1033\b0\loch
+free-electron lasers. ???}
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\loch\cf23\loch
 
 \par \pard\plain \s0\rtlch\af14\afs24\alang1025 \ltrch\lang1031\langfe1031\hich\af5\loch\sl288\slmult1\ql\widctlpar\hyphpar0\faauto\ltrpar\cf0\f5\fs22\lang1031\b\kerning1\dbch\af13\langfe1031\sl288\slmult1\li0\ri0\lin0\rin0\fi0\rtlch\afs28 \ltrch\lang1033\loch\lang1033\b0\loch