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LogSeq/assets/1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.edn

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LogSeq/assets/1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.edn

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+                          :page 2},
+               :content {:text "FLASH radiotherapy (FLASH-RT) is a promising cancer treatment under development, that involves an almost instantaneous delivery of a high radiation dose in only a few radiation pulses of ultra-high dose rate."},
+               :properties {:color "yellow"}}
+              {:id #uuid "659b0b80-3beb-4b61-9f5e-12965650cedb",
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+                          :page 2},
+               :content {:text "The limited energy of medical electron beams, only suitable for treatment of superficial or shallow tumours, boost treatments and operative scars [26], becomes a significant obstacle for treatment of deep-seated tumours. The application of very high energy electron (VHEE) [27] beams with energies exceeding 100 MeV could address the limitation of penetration depth and allow a therapeutic dose to be delivered to a deepseated tumour using FLASH regimes but requires huge accelerators for"},
+               :properties {:color "yellow"}}
+              {:id #uuid "659b0bce-2a9f-4f58-9fc3-274297d5c510",
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+               :content {:text "The actual accelerator structure of a laser driven electron accelerator is only a few cm in size and can reach energies up to GeV [28]. Laserdriven particle accelerators, which are being considered as the next generation of compact and cost-effective accelerators for radiotherapy with VHEE [29] as well as protons [30], can deliver ultra-short radiation pulses of extremely high dose rate (up to 109 – 1012 Gy/s)"},
+               :properties {:color "yellow"}}
+              {:id #uuid "659b0cb3-7710-4992-85c4-a42d38baa74f",
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+               :content {:text "However, extended studies with FLASH parameters are needed before the Fricke dosimetry can be used as primary standard in UHPDR electron beams. Such studies will be carried out by as part of work package 1 (WP 1) of UHDpulse."},
+               :properties {:color "yellow"}}
+              {:id #uuid "659b0db6-1445-4527-b359-a6a6fefc121a",
+               :page 10,
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+               :content {:text "In addition, it is planned to explore beam current transformers(BCT), such as AC Current Transformer (ACCT) or Integrating Current Transformer (ICT). These devices are promising, even though they are not used in clinical settings. "},
+               :properties {:color "yellow"}}
+              {:id #uuid "659b1b51-bca4-40f3-aa05-fd34eb2af1ba",
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+               :content {:text "nvestigating ion recombination in ionization chambers under such conditions"},
+               :properties {:color "yellow"}}],
+ :extra {:page 6}}

LogSeq/assets/CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.edn

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+               :content {:text "each beam particle is simulated individually there are no collective or stochastic effects "},
+               :properties {:color "yellow"}}],
+ :extra {:page 8}}

LogSeq/assets/Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.edn

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+{:highlights [{:id #uuid "659d48fe-31bb-48ad-a720-1267f7ff5f1f",
+               :page 67,
+               :position {:bounding {:x1 289.66595458984375,
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+               :content {:text " For the IMAGE beamline, energies between 8 keV and 40 keV"},
+               :properties {:color "yellow"}}],
+ :extra {:page 67}}

LogSeq/assets/Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.edn

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+               :content {:text "s highly collimated, quasi-parallel arrays of X-ray microbeams of 50-600 keV,"},
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LogSeq/assets/US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.edn

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LogSeq/assets/s13246-023-01266-z_FLASH_meta_study_1704658773663_0.edn

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+               :content {:text "A major omission in many publications is a solid reporting on dosimetry and quality control"},
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+               :content {:text " Future work focusing on which dose rates, irradiation times, reactive species, and biochemical conditions optimally promote a beneficial particle-FLASH effect will contribute greatly towards progression of this phenomenon into clinica"},
+               :properties {:color "yellow"}}
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+               :content {:text " However, there are several areas which must be understood before this treatment modality can be translated safely in clinical setting"},
+               :properties {:color "yellow"}}],
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LogSeq/assets/s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.edn

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LogSeq/logseq/config.edn

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+{:meta/version 1
+
+ ;; Set the preferred format.
+ ;; Available options:
+ ;; - Markdown (default)
+ ;; - Org
+ ;; :preferred-format "Markdown"
+
+ ;; Set the preferred workflow style.
+ ;; Available options:
+ ;; - :now for NOW/LATER style (default)
+ ;; - :todo for TODO/DOING style
+ :preferred-workflow :now
+
+ ;; Exclude directories/files.
+ ;; Example usage:
+ ;; :hidden ["/archived" "/test.md" "../assets/archived"]
+ :hidden []
+
+ ;; Define the default journal page template.
+ ;; Enter the template name between the quotes.
+ :default-templates
+ {:journals ""}
+
+ ;; Set a custom date format for the journal page title.
+ ;; Default value: "MMM do, yyyy"
+ ;; e.g., "Jan 19th, 2038"
+ ;; Example usage e.g., "Tue 19th, Jan 2038"
+ ;; :journal/page-title-format "EEE do, MMM yyyy"
+
+ ;; Specify the journal filename format using a valid date format string.
+ ;; !Warning:
+ ;;   This configuration is not retroactive and affects only new journals.
+ ;;   To show old journal files in the app, manually rename the files in the
+ ;;   journal directory to match the new format.
+ ;; Default value: "yyyy_MM_dd"
+ ;; :journal/file-name-format "yyyy_MM_dd"
+
+ ;; Enable tooltip preview on hover.
+ ;; Default value: true
+ :ui/enable-tooltip? true
+
+ ;; Display brackets [[]] around page references.
+ ;; Default value: true
+ ;; :ui/show-brackets? true
+
+ ;; Display all lines of a block when referencing ((block)).
+ ;; Default value: false
+ :ui/show-full-blocks? false
+
+ ;; Automatically expand block references when zooming in.
+ ;; Default value: true
+ :ui/auto-expand-block-refs? true
+
+ ;; Enable Block timestamps.
+ ;; Default value: false
+ :feature/enable-block-timestamps? false
+
+ ;; Disable accent marks when searching.
+ ;; After changing this setting, rebuild the search index by pressing (^C ^S).
+ ;; Default value: true
+ :feature/enable-search-remove-accents? true
+
+ ;; Enable journals.
+ ;; Default value: true
+ ;; :feature/enable-journals? true
+
+ ;; Enable flashcards.
+ ;; Default value: true
+ ;; :feature/enable-flashcards? true
+
+ ;; Enable whiteboards.
+ ;; Default value: true
+ ;; :feature/enable-whiteboards? true
+
+ ;; Disable the journal's built-in 'Scheduled tasks and deadlines' query.
+ ;; Default value: false
+ ;; :feature/disable-scheduled-and-deadline-query? false
+
+ ;; Specify the number of days displayed in the future for
+ ;; the 'scheduled tasks and deadlines' query.
+ ;; Example usage:
+ ;; Display all scheduled and deadline blocks for the next 14 days:
+ ;; :scheduled/future-days 14
+ ;; Default value: 7
+ ;; :scheduled/future-days 7
+
+ ;; Specify the first day of the week.
+ ;; Available options:
+ ;;  - integer from 0 to 6 (Monday to Sunday)
+ ;; Default value: 6 (Sunday)
+ :start-of-week 6
+
+ ;; Specify a custom CSS import.
+ ;; This option takes precedence over the local `logseq/custom.css` file.
+ ;; Example usage:
+ ;; :custom-css-url "@import url('https://cdn.jsdelivr.net/gh/dracula/logseq@master/custom.css');"
+
+ ;; Specify a custom JS import.
+ ;; This option takes precedence over the local `logseq/custom.js` file.
+ ;; Example usage:
+ ;; :custom-js-url "https://cdn.logseq.com/custom.js"
+
+ ;; Set a custom Arweave gateway
+ ;; Default gateway: https://arweave.net
+ ;; :arweave/gateway "https://arweave.net"
+
+ ;; Set bullet indentation when exporting
+ ;; Available options:
+ ;;  - `:eight-spaces` as eight spaces
+ ;;  - `:four-spaces` as four spaces
+ ;;  - `:two-spaces` as two spaces
+ ;;  - `:tab` as a tab character (default)
+ ;; :export/bullet-indentation :tab
+
+ ;; Publish all pages within the Graph
+ ;; Regardless of whether individual pages have been marked as public.
+ ;; Default value: false
+ ;; :publishing/all-pages-public? false
+
+ ;; Define the default home page and sidebar status.
+ ;; If unspecified, the journal page will be loaded on startup and the right sidebar will stay hidden.
+ ;; The `:page` value represents the name of the page displayed at startup.
+ ;; Available options for `:sidebar` are:
+ ;; - "Contents" to display the Contents page in the right sidebar.
+ ;; - A specific page name to display in the right sidebar.
+ ;; - An array of multiple pages, e.g., ["Contents" "Page A" "Page B"].
+ ;; If `:sidebar` remains unset, the right sidebar will stay hidden.
+ ;; Examples:
+ ;; 1. Set "Changelog" as the home page and display "Contents" in the right sidebar:
+ ;; :default-home {:page "Changelog", :sidebar "Contents"}
+ ;; 2. Set "Jun 3rd, 2021" as the home page without the right sidebar:
+ ;; :default-home {:page "Jun 3rd, 2021"}
+ ;; 3. Set "home" as the home page and display multiple pages in the right sidebar:
+ ;; :default-home {:page "home", :sidebar ["Page A" "Page B"]}
+
+ ;; Set the default location for storing notes.
+ ;; Default value: "pages"
+ ;; :pages-directory "pages"
+
+ ;; Set the default location for storing journals.
+ ;; Default value: "journals"
+ ;; :journals-directory "journals"
+
+ ;; Set the default location for storing whiteboards.
+ ;; Default value: "whiteboards"
+ ;; :whiteboards-directory "whiteboards"
+
+ ;; Enabling this option converts
+ ;; [[Grant Ideas]] to [[file:./grant_ideas.org][Grant Ideas]] for org-mode.
+ ;; For more information, visit https://github.com/logseq/logseq/issues/672
+ ;; :org-mode/insert-file-link? false
+
+ ;; Configure custom shortcuts.
+ ;; Syntax:
+ ;; 1. + indicates simultaneous key presses, e.g., `Ctrl+Shift+a`.
+ ;; 2. A space between keys represents key chords, e.g., `t s` means
+ ;;    pressing `t` followed by `s`.
+ ;; 3. mod refers to `Ctrl` for Windows/Linux and `Command` for Mac.
+ ;; 4. Use false to disable a specific shortcut.
+ ;; 5. You can define multiple bindings for a single action, e.g., ["ctrl+j" "down"].
+ ;; The full list of configurable shortcuts is available at:
+ ;; https://github.com/logseq/logseq/blob/master/src/main/frontend/modules/shortcut/config.cljs
+ ;; Example:
+ ;; :shortcuts
+ ;; {:editor/new-block       "enter"
+ ;;  :editor/new-line        "shift+enter"
+ ;;  :editor/insert-link     "mod+shift+k"
+ ;;  :editor/highlight       false
+ ;;  :ui/toggle-settings     "t s"
+ ;;  :editor/up              ["ctrl+k" "up"]
+ ;;  :editor/down            ["ctrl+j" "down"]
+ ;;  :editor/left            ["ctrl+h" "left"]
+ ;;  :editor/right           ["ctrl+l" "right"]}
+ :shortcuts {}
+
+ ;; Configure the behavior of pressing Enter in document mode.
+ ;; if set to true, pressing Enter will create a new block.
+ ;; Default value: false
+ :shortcut/doc-mode-enter-for-new-block? false
+
+ ;; Block content larger than `block/content-max-length` will not be searchable
+ ;; or editable for performance.
+ ;; Default value: 10000
+ :block/content-max-length 10000
+
+ ;; Display command documentation on hover.
+ ;; Default value: true
+ :ui/show-command-doc? true
+
+ ;; Display empty bullet points.
+ ;; Default value: false
+ :ui/show-empty-bullets? false
+
+ ;; Pre-defined :view function to use with advanced queries.
+ :query/views
+ {:pprint
+  (fn [r] [:pre.code (pprint r)])}
+
+ ;; Advanced queries `:result-transform` function.
+ ;; Transform the query result before displaying it.
+ :query/result-transforms
+ {:sort-by-priority
+  (fn [result] (sort-by (fn [h] (get h :block/priority "Z")) result))}
+
+ ;; The following queries will be displayed at the bottom of today's journal page.
+ ;; The "NOW" query returns tasks with "NOW" or "DOING" status.
+ ;; The "NEXT" query returns tasks with "NOW", "LATER", or "TODO" status.
+ :default-queries
+ {:journals
+  [{:title "🔨 NOW"
+    :query [:find (pull ?h [*])
+            :in $ ?start ?today
+            :where
+            [?h :block/marker ?marker]
+            [(contains? #{"NOW" "DOING"} ?marker)]
+            [?h :block/page ?p]
+            [?p :block/journal? true]
+            [?p :block/journal-day ?d]
+            [(>= ?d ?start)]
+            [(<= ?d ?today)]]
+    :inputs [:14d :today]
+    :result-transform (fn [result]
+                        (sort-by (fn [h]
+                                   (get h :block/priority "Z")) result))
+    :group-by-page? false
+    :collapsed? false}
+   {:title "📅 NEXT"
+    :query [:find (pull ?h [*])
+            :in $ ?start ?next
+            :where
+            [?h :block/marker ?marker]
+            [(contains? #{"NOW" "LATER" "TODO"} ?marker)]
+            [?h :block/page ?p]
+            [?p :block/journal? true]
+            [?p :block/journal-day ?d]
+            [(> ?d ?start)]
+            [(< ?d ?next)]]
+    :inputs [:today :7d-after]
+    :group-by-page? false
+    :collapsed? false}]}
+
+ ;; Add custom commands to the command palette
+ ;; Example usage:
+ ;; :commands
+ ;; [
+ ;;  ["js" "Javascript"]
+ ;;  ["md" "Markdown"]
+ ;;  ]
+ :commands []
+
+ ;; Enable collapsing blocks with titles but no children.
+ ;; By default, only blocks with children can be collapsed.
+ ;; Setting `:outliner/block-title-collapse-enabled?` to true allows collapsing
+ ;; blocks with titles (multiple lines) and content. For example:
+ ;; - block title
+ ;;   block content
+ ;; Default value: false
+ :outliner/block-title-collapse-enabled? false
+
+ ;; Macros replace texts and will make you more productive.
+ ;; Example usage:
+ ;; Change the :macros value below to:
+ ;; {"poem" "Rose is $1, violet's $2. Life's ordered: Org assists you."}
+ ;; input "{{poem red,blue}}"
+ ;; becomes
+ ;; Rose is red, violet's blue. Life's ordered: Org assists you.
+ :macros {}
+
+ ;; Configure the default expansion level for linked references.
+ ;; For example, consider the following block hierarchy:
+ ;; - a [[page]] (level 1)
+ ;;   - b        (level 2)
+ ;;     - c      (level 3)
+ ;;       - d    (level 4)
+ ;;
+ ;; With the default value of level 2, block b will be collapsed.
+ ;; If the level's value is set to 3, block c will be collapsed.
+ ;; Default value: 2
+ :ref/default-open-blocks-level 2
+
+ ;; Configure the threshold for linked references before collapsing.
+ ;; Default value: 100
+ :ref/linked-references-collapsed-threshold 50
+
+ ;; Graph view configuration.
+ ;; Example usage:
+ ;; :graph/settings
+ ;; {:orphan-pages?   true   ; Default value: true
+ ;;  :builtin-pages?  false  ; Default value: false
+ ;;  :excluded-pages? false  ; Default value: false
+ ;;  :journal?        false} ; Default value: false
+
+ ;; Favorites to list on the left sidebar
+ :favorites ["risk management" "gegenüberstellung" "Collective Effects"]
+
+ ;; Set flashcards interval.
+ ;; Expected value:
+ ;; - Float between 0 and 1
+ ;; higher values result in faster changes to the next review interval.
+ ;; Default value: 0.5
+ ;; :srs/learning-fraction 0.5
+
+ ;; Set the initial interval after the first successful review of a card.
+ ;; Default value: 4
+ ;; :srs/initial-interval 4
+
+ ;; Hide specific block properties.
+ ;; Example usage:
+ ;; :block-hidden-properties #{:public :icon}
+
+ ;; Create a page for all properties.
+ ;; Default value: true
+ :property-pages/enabled? true
+
+ ;; Properties to exclude from having property pages
+ ;; Example usage:
+ ;; :property-pages/excludelist #{:duration :author}
+
+ ;; By default, property value separated by commas will not be treated as
+ ;; page references. You can add properties to enable it.
+ ;; Example usage:
+ ;; :property/separated-by-commas #{:alias :tags}
+
+ ;; Properties that are ignored when parsing property values for references
+ ;; Example usage:
+ ;; :ignored-page-references-keywords #{:author :website}
+
+ ;; logbook configuration.
+ ;; :logbook/settings
+ ;; {:with-second-support? false ;limit logbook to minutes, seconds will be eliminated
+ ;;  :enabled-in-all-blocks true ;display logbook in all blocks after timetracking
+ ;;  :enabled-in-timestamped-blocks false ;don't display logbook at all
+ ;; }
+
+ ;; Mobile photo upload configuration.
+ ;; :mobile/photo
+ ;; {:allow-editing? true
+ ;;  :quality        80}
+
+ ;; Mobile features options
+ ;; Gestures
+ ;; Example usage:
+ ;; :mobile
+ ;; {:gestures/disabled-in-block-with-tags ["kanban"]}
+
+ ;; Extra CodeMirror options
+ ;; See https://codemirror.net/5/doc/manual.html#config for possible options
+ ;; Example usage:
+ ;; :editor/extra-codemirror-options
+ ;; {:lineWrapping  false  ; Default value: false
+ ;;  :lineNumbers   true   ; Default value: true
+ ;;  :readOnly      false} ; Default value: false
+
+ ;; Enable logical outdenting
+ ;; Default value: false
+ ;; :editor/logical-outdenting? false
+
+ ;; Prefer pasting the file when text and a file are in the clipboard.
+ ;; Default value: false
+ ;; :editor/preferred-pasting-file? false
+
+ ;; Quick capture templates for receiving content from other apps.
+ ;; Each template contains three elements {time}, {text} and {url}, which can be auto-expanded
+ ;; by receiving content from other apps. Note: the {} cannot be omitted.
+ ;; - {time}: capture time
+ ;; - {date}: capture date using current date format, use `[[{date}]]` to get a page reference
+ ;; - {text}: text that users selected before sharing.
+ ;; - {url}: URL or assets path for media files stored in Logseq.
+ ;; You can also reorder them or use only one or two of them in the template.
+ ;; You can also insert or format any text in the template, as shown in the following examples.
+ ;; :quick-capture-templates
+ ;; {:text "[[quick capture]] **{time}**: {text} from {url}"
+ ;;  :media "[[quick capture]] **{time}**: {url}"}
+
+ ;; Quick capture options.
+ ;; - insert-today?   Insert the capture at the end of today's journal page (boolean).
+ ;; - redirect-page?  Redirect to the quick capture page after capturing (boolean).
+ ;; - default-page    The default page to capture to if insert-today? is false (string).
+ ;; :quick-capture-options
+ ;; {:insert-today? false           ;; Default value: true
+ ;;  :redirect-page? false          ;; Default value: false
+ ;;  :default-page "quick capture"} ;; Default page: "quick capture"
+
+ ;; File sync options
+ ;; Ignore these files when syncing, regexp is supported.
+ ;; :file-sync/ignore-files []
+
+ ;; Configure the Enter key behavior for
+ ;; context-aware editing with DWIM (Do What I Mean).
+ ;; context-aware Enter key behavior implies that pressing Enter will
+ ;; have different outcomes based on the context.
+ ;; For instance, pressing Enter within a list generates a new list item,
+ ;; whereas pressing Enter in a block reference opens the referenced block.
+ ;; :dwim/settings
+ ;; {:admonition&src?  true        ;; Default value: true
+ ;;  :markup?          false       ;; Default value: false
+ ;;  :block-ref?       true        ;; Default value: true
+ ;;  :page-ref?        true        ;; Default value: true
+ ;;  :properties?      true        ;; Default value: true
+ ;;  :list?            false}      ;; Default value: false
+
+ ;; Configure the escaping method for special characters in page titles.
+ ;; Warning:
+ ;;   This is a dangerous operation. To modify the setting,
+ ;;   access the 'Filename format' setting and follow the instructions.
+ ;;   Otherwise, You may need to manually rename all affected files and
+ ;;   re-index them on all clients after synchronization.
+ ;;   Incorrect handling may result in messy page titles.
+ ;; Available options:
+ ;;   - :triple-lowbar (default)
+ ;;      ;use triple underscore `___` for slash `/` in page title
+ ;;      ;use Percent-encoding for other invalid characters
+ :file/name-format :triple-lowbar}

LogSeq/pages/Collective Effects.md

@@ -0,0 +1,10 @@
+- CSR
+- Space charge
+- Touschek
+- IBS: shorter bunch length lead to stronger increase in epread -> gets more important for short pulses like in flashRT #IBS
+	- ![s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace.pdf](../assets/s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.pdf)
+	- ((6599806e-ba8f-4549-9c88-f99940e33e96)) (for longitudinal description see s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace.pdf eq.30
+- micro-bunching
+- übergangsstrahlung, bremsstrahlung?
+- TODO:
+- summarize which effects could be relevant, then see which are considered at the moment for medical linacs, especiallty flash/microbeams, and then it is clear which need to be considered, thats what I plan to do....

LogSeq/pages/contents.md

@@ -0,0 +1 @@
+-

LogSeq/pages/gegenüberstellung.md

@@ -0,0 +1,56 @@
+- ![s13246-023-01266-z_FLASH_meta_study.pdf](../assets/s13246-023-01266-z_FLASH_meta_study_1704658773663_0.pdf)
+- ![1-s2.0-S1120179720302362-main_Metrology_for_flash.pdf](../assets/1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.pdf)
+- ![CERN-2018-011-CP pages 45 - 55_BDSIM_GEANT4_no_collective_effects.pdf](../assets/CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.pdf)
+-
+-
+- vorher = Status quo
+- RT important
+- promising FLASH
+- not yet in clinical settings ((659b0870-2609-4ae6-ad6f-f179225fb80d))
+- just now first clinical standard?
+- not easy as accelerator based and most clinical linacs not sufficient
+- still much work to be done in metrology(dosimetry and quality control), required for reliability in deposited dose,
+  :LOGBOOK:
+  CLOCK: [2024-01-07 Sun 21:40:02]
+  :END:
+	- normal primary standards not directly applicable for short pulses -> UHDpulse project ((659b0cb3-7710-4992-85c4-a42d38baa74f))
+	- deviation between measured dose and simulated, ((659b077e-8b51-4d4b-b5f1-35d08f4f33f5))
+		- one reason is due to non-linearities in the detector at these ultra-high dose rates (e.g. ion re-combination) in detector) ((659b1b51-bca4-40f3-aa05-fd34eb2af1ba))
+		- another reason could be in the simulations of the expected dose, as in nearly all cases one beam-matter interaction is considered but no interaction between the electrons (e.g. BDSIM) ((659b1d67-80a1-4d62-8fa3-99e36c4eb11d))
+		-
+	- main diagnostic at the moment focuses on does measurements?? very limited beam based diagnostic in medical accelerators used ((659b0db6-1445-4527-b359-a6a6fefc121a))
+-
+- not yet clear what exactly are the optimal parameters when it comes to pulse shortness and high dose ((659b083d-a051-48cf-a962-ad08737f1311)) (see what is possible when considering limitations due to collective effects)
+- current medical accelerators limited to below 20MeV, only allow superficial or shallow tumors, ((659b0b80-3beb-4b61-9f5e-12965650cedb)) -> either got to dedicated linacs or maybe laser driven accelerators? ((659b0bce-2a9f-4f58-9fc3-274297d5c510))
+- and microbeam, mainly with x-ray, as electron beams diverge fast, or with GRID therapy, but similar potential as flash to spare healthy tissue ![1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy.pdf](../assets/1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.pdf)
+- spatially structured/modulated beams (non-Gaussian) also relevant to accommodate irregular/uneven patient surfaces , very recent patent on passive intensity modulation for electron beams ((659b28fe-16bb-4b12-97e6-eb219198a681)) , ![US20200023200A1_patent_for_passive_electron_beam_modulation.pdf](../assets/US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.pdf)
+-
+-
+- little to no mentioning of consideration of collective effects in the source accelerators, which (from accelerator physics point of view) is expected play an ever increasing role with decreasing pulse length and increasing pulse intensity, as well as with spatial structuring of the beam
+-
+- "OPAL (Object Oriented Particle Accelerator Library) is an open source 
+  C++ framework for general particle accelerator simulations including 3D 
+  space charge, short range wake fields and particle matter interaction." (https://gitlab.psi.ch/OPAL)
+	- did not find any publication using OPAL for FLASH therapy, found mainly for proton therapy
+	- first starting point?
+- --------------
+- I want to investigate how different collective effects known in the accelerator beam dynamics affect the beam transport and beam-matter interaction in novel electron radiotherapy methods, such as FLASH RT, microbeam RT and electron conformal therapy (ECT)
+- to have experimental test bed, use FLUTE for short pulses and spatial light modulator to structure beam, e.g. micro beams, or non-gaussian distribution.....
+- measure dose for different sets, and cross check with improved simulations containing collective effects,
+- also include accelerator diagnostics more into modelling ...
+-
+- how: MC (opal?), covariance matrizes (statistic particle ensemble), phase space density with wake fields, Particle tracking...
+- -----------------------------------
+- result is improved modelling, now including collective effects and that not only in accelerator but also in beam transport trough matter
+- but also knowledge which effects relevant
+- more knowledge about which beam conditions for flash possible to generate with which accelerator parameters/requirements and what diagnostic in accelerator necessary, input for next generation medical accelerators
+- ideally start to end simulation for RT with (temporal and/or spatial) structured beam including collective effects
+	- prediction of phase space in target
+	- And as a second step, it might allow to consider effects of the beam transport already during the generation of the beam.
+	- Aiming towards the generation of a spatial distribution which preemptively compensates for the expected changes, possibly allowing arbitrary user-definable final distributions.
+-
+-
+-
+- --------------------------
+-
+- ???what about some kind of CSR impedance caused by photons emitted when scattered which then hit again other electrons and change energy? does this make sense, as then photon also hit matter, and not very directed so also not very probable to hit other beam electrons, but maybe from transition radiation between dirfferent materials, how is the emission angle from transition radiation? forwards? backwards? both could interact with electrons close by /behind...especially in ultra high density beams...

LogSeq/pages/hls__1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.md

@@ -0,0 +1,2 @@
+file:: [1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.pdf](../assets/1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.pdf)
+file-path:: ../assets/1-s2.0-S0958394702000869-main_spatial_fractionation_electron_grid_therapy_1704662558313_0.pdf

LogSeq/pages/hls__1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.md

@@ -0,0 +1,33 @@
+file:: [1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.pdf](../assets/1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.pdf)
+file-path:: ../assets/1-s2.0-S1120179720302362-main_Metrology_for_flash_1704659443526_0.pdf
+
+- FLASH radiotherapy (FLASH-RT) is a promising cancer treatment under development, that involves an almost instantaneous delivery of a high radiation dose in only a few radiation pulses of ultra-high dose rate.
+  ls-type:: annotation
+  hl-page:: 2
+  hl-color:: yellow
+  id:: 659b0a42-721f-4625-be01-6549df80fa12
+- The limited energy of medical electron beams, only suitable for treatment of superficial or shallow tumours, boost treatments and operative scars [26], becomes a significant obstacle for treatment of deep-seated tumours. The application of very high energy electron (VHEE) [27] beams with energies exceeding 100 MeV could address the limitation of penetration depth and allow a therapeutic dose to be delivered to a deepseated tumour using FLASH regimes but requires huge accelerators for
+  ls-type:: annotation
+  hl-page:: 2
+  hl-color:: yellow
+  id:: 659b0b80-3beb-4b61-9f5e-12965650cedb
+- The actual accelerator structure of a laser driven electron accelerator is only a few cm in size and can reach energies up to GeV [28]. Laserdriven particle accelerators, which are being considered as the next generation of compact and cost-effective accelerators for radiotherapy with VHEE [29] as well as protons [30], can deliver ultra-short radiation pulses of extremely high dose rate (up to 109 – 1012 Gy/s)
+  ls-type:: annotation
+  hl-page:: 2
+  hl-color:: yellow
+  id:: 659b0bce-2a9f-4f58-9fc3-274297d5c510
+- However, extended studies with FLASH parameters are needed before the Fricke dosimetry can be used as primary standard in UHPDR electron beams. Such studies will be carried out by as part of work package 1 (WP 1) of UHDpulse.
+  ls-type:: annotation
+  hl-page:: 6
+  hl-color:: yellow
+  id:: 659b0cb3-7710-4992-85c4-a42d38baa74f
+- In addition, it is planned to explore beam current transformers(BCT), such as AC Current Transformer (ACCT) or Integrating Current Transformer (ICT). These devices are promising, even though they are not used in clinical settings. 
+  ls-type:: annotation
+  hl-page:: 10
+  hl-color:: yellow
+  id:: 659b0db6-1445-4527-b359-a6a6fefc121a
+- nvestigating ion recombination in ionization chambers under such conditions
+  ls-type:: annotation
+  hl-page:: 6
+  hl-color:: yellow
+  id:: 659b1b51-bca4-40f3-aa05-fd34eb2af1ba

LogSeq/pages/hls__CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.md

@@ -0,0 +1,8 @@
+file:: [CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.pdf](../assets/CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.pdf)
+file-path:: ../assets/CERN-2018-011-CP_pages_45_-_55_BDSIM_GEANT4_no_collective_effects_1704664399165_0.pdf
+
+- each beam particle is simulated individually there are no collective or stochastic effects 
+  ls-type:: annotation
+  hl-page:: 8
+  hl-color:: yellow
+  id:: 659b1d67-80a1-4d62-8fa3-99e36c4eb11d

LogSeq/pages/hls__Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.md

@@ -0,0 +1,8 @@
+file:: [Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.pdf](../assets/Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.pdf)
+file-path:: ../assets/Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.pdf
+
+- For the IMAGE beamline, energies between 8 keV and 40 keV
+  ls-type:: annotation
+  hl-page:: 67
+  hl-color:: yellow
+  id:: 659d48fe-31bb-48ad-a720-1267f7ff5f1f

LogSeq/pages/hls__Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.md

@@ -0,0 +1,8 @@
+file:: [Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.pdf](../assets/Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.pdf)
+file-path:: ../assets/Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.pdf
+
+- s highly collimated, quasi-parallel arrays of X-ray microbeams of 50-600 keV,
+  ls-type:: annotation
+  hl-page:: 1
+  hl-color:: yellow
+  id:: 659d497c-e894-4c0e-ab40-d50fbc7201d4

LogSeq/pages/hls__US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.md

@@ -0,0 +1,10 @@
+file:: [US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.pdf](../assets/US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.pdf)
+file-path:: ../assets/US20200023200A1_patent_for_passive_electron_beam_modulation_1704662602575_0.pdf
+
+- [:span]
+  ls-type:: annotation
+  hl-page:: 1
+  hl-color:: yellow
+  id:: 659b28fe-16bb-4b12-97e6-eb219198a681
+  hl-type:: area
+  hl-stamp:: 1704667388151

LogSeq/pages/hls__s13246-023-01266-z_FLASH_meta_study_1704658773663_0.md

@@ -0,0 +1,18 @@
+file:: [s13246-023-01266-z_FLASH_meta_study_1704658773663_0.pdf](../assets/s13246-023-01266-z_FLASH_meta_study_1704658773663_0.pdf)
+file-path:: ../assets/s13246-023-01266-z_FLASH_meta_study_1704658773663_0.pdf
+
+- A major omission in many publications is a solid reporting on dosimetry and quality control
+  ls-type:: annotation
+  hl-page:: 28
+  hl-color:: yellow
+  id:: 659b077e-8b51-4d4b-b5f1-35d08f4f33f5
+- Future work focusing on which dose rates, irradiation times, reactive species, and biochemical conditions optimally promote a beneficial particle-FLASH effect will contribute greatly towards progression of this phenomenon into clinica
+  ls-type:: annotation
+  hl-page:: 28
+  hl-color:: yellow
+  id:: 659b083d-a051-48cf-a962-ad08737f1311
+- However, there are several areas which must be understood before this treatment modality can be translated safely in clinical setting
+  ls-type:: annotation
+  hl-page:: 28
+  hl-color:: yellow
+  id:: 659b0870-2609-4ae6-ad6f-f179225fb80d

LogSeq/pages/hls__s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.md

@@ -0,0 +1,10 @@
+file:: [s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.pdf](../assets/s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.pdf)
+file-path:: ../assets/s41598-021-87041-0_matrix_model_for_collective_phenomena_in_ebeams_long_phasespace_1704558674664_0.pdf
+
+- [:span]
+  ls-type:: annotation
+  hl-page:: 5
+  hl-color:: yellow
+  id:: 6599806e-ba8f-4549-9c88-f99940e33e96
+  hl-type:: area
+  hl-stamp:: 1704558700427

LogSeq/pages/risk management.md

@@ -0,0 +1,14 @@
+- generell verständnis von collective effects, in this type of linear accelerator interessting?
+- was wird in treibern für FEL gemacht, aber da ist ja definitiv höhere energie
+- was ist die electronen quelle in laser plasma bescheluniger? hilft es da
+-
+- Detector tests at FLUTE?
+- cstart?
+- Protonen in Heidelberg, was ist da mit collective effects
+-
+-
+- MRT
+	- photon energy at IMAGE 40keV ![Masterthesis_Katharina_Mayer_small.pdf copy (optimized).pdf](../assets/Masterthesis_Katharina_Mayer_small.pdf_copy_(optimized)_1704806602975_0.pdf)((659d48fe-31bb-48ad-a720-1267f7ff5f1f))
+	- ESRF says ((659d497c-e894-4c0e-ab40-d50fbc7201d4)) ![Microbeam Radiation Therapy (MRT)_ESRF_webside.pdf](../assets/Microbeam_Radiation_Therapy_(MRT)_ESRF_webside_1704806743155_0.pdf)
+-
+-

Notizen_treffen_anke_24Jul2023.txt

@@ -81,9 +81,7 @@ TODO:
 - welche bestätigungen braucht es vom KIT und wie lange dauern die?
 
 - lern mehr über recombination factor in ionization chambers
- Indeed, ion
+ Indeed, ion recombination effects occurring at these regimes require large corrections for charge collection efficiency resulting in a large measurement uncertainty
-recombination effects occurring at these regimes require large corrections for charge collection
-efficiency resulting in a large measurement uncertainty
 
 (weird question can we use synchrotron light? from a bend of the electron transfer line, at least relative calibration? fast optical diode?)
 

anke_fragen.txt

@@ -52,3 +52,37 @@ wofür ist das gut, was hilft dass dann/nützt das dann, als ausblick ....cstart
 meisten diagnostic wird basierend auf den sachen die schon da sind, oder in kooperation mit ipe gebaut werden...
 CMOS über HEIKA, IPE
 leute in kooperations liste
+
+---------
+309,
+------------------
+cooperative wissenschaftler
+------------
+verständlich erklären
+--------
+noch alternative technische anwendung als zweit/backup...Bernhard holzapfel (supraleitend)
+vlt nicht kurz pulse sondern ehr räumliche strukturierung,, da ist colllective wichtig
+
+risk mitigation, mit spin-offs, ...
+
+strukturierter strahl für laser plasma driver
+------
+relevanz, novellty , anwendungsmöglichkeit
+aktuallität, originell
+
+-------
+injector linacs, da colllective effecte, überstahlen von monitoren
+
+dosis im patrient auf 5% im phantom 1% weil steile kurve- wasser oder graphit als standard
+
+für flash chemische dosimeter....zeigt veränderung....
+LET abhängig
+
+
+
+
+
+
+
+
+mal für erik formuliert: Ganz grob gesagt ist der Themenbereich den ich überlege zu bearbeiten, den Überlap beziehungsweise die Verknüpfung von Beschleuniger Simulationen mit Strahltransportsimulationen in Materie weiter zu verstärken. Insbesondere der Einfluss von kollektiven Effekten bei Strahlen mit den extremen Eigenschaften wie die kurzen, intensiven Pulse für FLASH oder auch räumlich modulierte Strahlen (daher auch das Interesse am SLM). Beim Transport der Strahlen durch Luft und Materie wird momentan in den aller meisten Fällen die Interaktion von Strahl-Teilchen miteinander nicht berücksichtigt. Das ganze würde ich unterstützen durch experimentelle Messungen (Strahleigenschaften und Dosimetry) und auch Tests von möglichen neuen Detektortypen für Dosimetry (wenn sich da Kollaborationen ergeben).

emmy_noether/.~lock.53_05_en_elan_projectdescription_draft.rtf#

@@ -1 +1 @@
-,mirbro,w-mirbro-pc-0,06.01.2024 13:41,file:///home/mirbro/.config/libreoffice/4;
+,mirbro,w-mirbro-pc-0,11.01.2024 12:02,file:///home/mirbro/.config/libreoffice/4;

emmy_noether/.~lock.53_200_en_elan_CV_draft.rtf#

@@ -1 +0,0 @@
-,mirbro,w-mirbro-pc-0,05.01.2024 11:52,file:///home/mirbro/.config/libreoffice/4;

first_sentences.txt

@@ -105,6 +105,8 @@ https://gepris.dfg.de/gepris/projekt/22505257 gemeinsames project
 
 - EGSnrc simulation of absorbed dose, as 2D/3D distribution plot???
      also electron fluence?
+
+- what about some kind of CSR impedance caused by photons emitted when scattered which then hit again other electrons and change energy? does this make sense, as then photon also hit matter, and not very directed so also not very probable to hit other beam electrons, but maybe from transition radiation between dirfferent materials, how is the emission angle from transition radiation? forwards? backwards? both could interact with electrons close by /behind...especially in ultra high density beams...
 --------------------
 develop predictions/simulations as well as select correct diagnostics
 test both with measurements

first_slides/2024-01_proposal.aux

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first_slides/2024-01_proposal.tex

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+
+% \usepackage{beamerthememaxiv}
+\usepackage[utf8]{inputenc}
+
+
+\usepackage{babel}
+\usepackage{fontenc}
+\usepackage{graphicx}
+\usepackage{tikz}
+\usepackage{animate}
+
+
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+
+
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+\end{tikzpicture}
+}
+
+
+
+\date{\today}
+
+\title[Proposal]{\Large{beam dynamics and collective effects in structured beams for advanced accelerator based radiation therapy
+}}
+\author[Miriam Brosi ]{Miriam Brosi}
+\begin{document}
+
+
+
+\begin{frame}
+\titlepage
+\end{frame}
+
+\begin{frame}{Motivation}
+
+The present advances in accelerator based RT, like FLASH RT or Microbeam RT,
+lead to operation parameters of the used accelerators that can not anymore be described by simple linear optics and beam dynamics. Instead, due to the development towards higher intensity combined with shorter pulse lengths and transverse modulations, the consideration of non-linear and complex optics as well as beam dynamics influenced by collective effects becomes necessary for accelerator RT sources.\\
+\vspace{0.5cm}
+%Applying this knowledge,...
+%Transfering ...
+% bringing together
+Further closing the gap between accelerator science and medical physics from the accelerator side is an important step and will help in paving the way towards accurate predictability, diagnostic and metrology of advanced RT with particle accelerators.
+% aims to greatly improve the applicability of these RT methods in the future.
+\end{frame}
+
+
+\begin{frame}{Status quo}%{Ausgangslage}
+
+\begin{itemize}
+ \item RT is an important tool in cancer therapy, continuous development towards improved tolerability and increase of the therapeutic window
+
+ \item two promising candidates recently: FLASH RT and spatially fractionated RT (MRT)
+ \item not yet in clinical settings
+% \item both show improved sparing of healthy tissue and reduction of secondary cancer also increasingly important due to increase in overall life expectancy
+\item both dependent on particle accelerators and most medical linacs not sufficient
+% \begin{itemize}
+%  \item for FLASH: to achieve the required intensity in short pulses, e.g. linear accelerators for electron FLASH RT
+%  \item for MRT: in case of x-ray beams, a high brilliant synchrotron light sources are required to provide sufficiently parallel propagating Microbeams
+% \end{itemize}
+\end{itemize}
+FLASH RT
+\begin{itemize}
+\item requirements on stability and metrology of the used beams not yet fulfilled
+\begin{itemize}
+\item primary standard of standard particle RT not directly applicable
+\item discrepancy observed between measured dose and simulated
+\item non-linearity in detectors at ultra-high dose rates (e.g. high ion recombination rate)\\
+$\rightarrow$ improved by UHDpulse project, still open questions
+\item simulation of dose does in most cases do not consider interaction between beam particles
+\item most diagnostic focuses on beam outside accelerator, potential of fast and accurate accelerator diagnostic not fully exploited (e.g. shot by shot charge, position, size, ... measurements)
+\end{itemize}
+\item optimal parameters such as pulse duration, intensity and energy not yet medically clear
+\begin{itemize}
+ \item input to possible parameter areas, that can be provided reliably by accelerators needed
+ \item new accelerator types (e.g. laser-based ones for higher energies) bring also different beam dynamic effects to be considered, such as high energy spread, shot-to-shot variation, ...
+\end{itemize}
+\end{itemize}
+\end{frame}
+
+
+\begin{frame}{Status quo}%{Ausgangslage}
+Spatially structured RT
+\begin{itemize}
+ \item Microbeam RT mainly studied with x-rays but similar potential for particle beams as demonstrated with GRID therapy
+\begin{itemize}
+\item modulation done mostly close to target
+\end{itemize}
+\item spatially modulated beams (non-Gaussian dose distribution) relevant to accommodate either irregular/uneven patient surfaces (e.g. electron conformal therapy ECT) or achieve homogeneous dose distributions
+\begin{itemize}
+ \item mostly handled by scanning, masks/collimators or bolus ECT
+\end{itemize}
+\end{itemize}
+
+% \vspace{cm}
+General
+\begin{itemize}
+ \item  no interaction between beam particles considered in most simulations (e.g. FLUKA, EGSnrc, BDSIM with Geant4)
+ \item OPAL does include 3D space charge, seems to mainly be used for proton therapy
+
+\end{itemize}
+
+\vspace{0.5cm}
+$\Rightarrow$
+Little to no mentioning of consideration of collective effects, which (from accelerator physics point of view) is expected to play an increasing role with decreasing pulse length and increasing pulse intensity, as well as with spatial structuring of the beam.
+\end{frame}
+
+\begin{frame}{Goals}
+I would like to investigate how and which collective effects known in the accelerator beam dynamics affect the beam transport, beam-matter interaction and diagnostics in novel electron radiotherapy methods with temporally and spatially structured beams.
+\begin{itemize}
+\item improve predictability of RT beam properties and deposited dose on target
+\begin{itemize}
+ \item improve understanding of dynamic in generation of short or spatially structured RT beams
+ \item investigate accelerator diagnostics that will be beneficial in new medical accelerators
+\item improve simulation of beam transport through matter by including collective effects
+\item contribute to development of improved dosimetry detectors by testing at variety of beam conditions
+\end{itemize}
+\item characterise possibility to generate different temporal and spatial distributions on target already during beam generation
+  \item provide start-to-end simulations of RT beams, from inside the accelerator through the air into the target by combining beam dynamics, beam-matter interaction and collective effects simulations
+\begin{itemize}
+ \item first step: direct prediction of the resulting temporal\&spatial distribution on target
+ \item second step: consider deformation in beam transport already during the beam generation
+\item aiming towards the generation of a spatial distribution which preemptively compensates for the expected changes, possibly allowing arbitrary user-definable final distributions
+\end{itemize}
+
+\end{itemize}
+\end{frame}
+
+
+\begin{frame}{Methods}
+\begin{itemize}
+ \item Experimental:\\
+ first test bed: FLUTE
+ \begin{itemize}
+  \item ultra-short pulses (variable length, and charge)
+  \item spatial light-modulator (modulate spatial distribution)
+  \item multitude of diagnostic (including virtual diagnostic via surrogate modeling)
+  \item possibly joined measurements to test detector prototypes? (e.g. for dosimetry of ultra short pulses, or maybe pixel detectors to resolve 2D distribution
+ \end{itemize}
+\item Theoretical:
+\begin{itemize}
+\item for accelerator dynamics start with existing simulation tools (ASTRA, AT, Ocelot, ...)
+\item for beam-matter interaction start with existing simulation tools (FLUKA, EGSnrc, BDSIM, OPAL, ...)
+\item several option to include collective effects in beam transport through matter
+\begin{itemize}
+ \item Monte Carlo simulations
+ \item particle tracking
+\item phase-space density propagation
+ \item covariance matrices (based on statistical particle ensembles)
+\end{itemize}
+\end{itemize}
+\item regular cross-checks between experimental results and improved simulations
+\end{itemize}
+\end{frame}
+
+%
+% \begin{frame}{Existing infrastructure and knowhow (1)}
+% Environment:
+% \begin{itemize}
+%  \item ATP - accelerators as well as detector technologies
+%  \item HEIKA - Heidelberg Karlsruhe Strategic Partnership
+%  \item new KIT Center Health Technologies
+%  \item possible Cluster of Excellence AccelerateRT
+% \end{itemize}
+%
+% Accelerators:
+% \begin{itemize}
+% \item FLUTE electron linear accelerator as electron source up to 40MeV and ultra short pulses down to femtoseconds
+% \begin{itemize}
+% \item virtual diagnostic, spatial light modulator, ...
+% \end{itemize}
+% \item KARA storage ring as synchrotron light source for x-ray (and also THz ?)
+% \begin{itemize}
+%  \item extensive diagnostics, variable, special operation modes, ...
+% \end{itemize}
+% \item in the planing, CSTART innovative non-equilibrium storage ring will provide the possibility to study dynamics of changing pulse lengths
+% \item coming, laser based accelerator
+% \end{itemize}
+% \end{frame}
+%
+% \begin{frame}{Existing infrastructure and knowhow (2)}
+% Me:
+% \begin{itemize}
+% \item experience in longitudinal as well as transverse collective effects and instabilities influencing the electron bunch shape in all dimensions
+% \item in general, investigating phenomena occurring under extreme operation modes, e.g. high charge, small transverse bunch-size, short bunch-length, sub-structures, ...
+% \item on rings but focused on single bunch effects transferrable to linacs
+% \item simulations of non-linear optics and beam dynamics, collective effects
+% \item extensive experimental studies and measurements
+% \item used diagnostics: electron-beam based as well as synchrotron-radiation based\\ as well as improved and further-developed diagnostic methods
+% \item data analysis of complex, big datasets with, amongst others, Python and HPC (high performance computing)
+% \end{itemize}
+% \end{frame}
+
+
+%
+% \begin{frame}{Plan}
+% Simulations:
+% \begin{itemize}
+%  \item start with simulations on the 6D particle distribution expected at the exit of the linear accelerator
+%  \item followed by simulation of the beam dynamics for this particle distribution on its trajectory to the target
+%  \begin{itemize}
+%   \item based on existing simulation tools and models, e.g. transport/covariance matrices combined with average scattering angles based on existing beam-matter interaction descriptions
+%  \end{itemize}
+%  \item add collective effects, e.g. space charge, via impedances and/or particle tracking
+% \end{itemize}
+% Experimental in parallel:
+% \begin{itemize}
+% \item survey of required vs available diagnostics to measure 6D particle distribution at different positions in the linac, e.g. virtual diagnostic available
+% \item measurements of 6D particle distribution at accelerator exit based on starting distribution
+%  \item experimental studies of the propagation of 6D particle distribution through air and/or water, including acquiring and set up of necessary diagnostic/detectors/targets
+% \item extend studies to X-ray(/THz?) at synchrotron light source (KARA)
+% \end{itemize}
+%
+% periodical cross-checks between experimental results and simulations to iteratively improve both
+%
+% \end{frame}
+%
+% %
+% \begin{frame}[t]{Simulated energy spread - 2nd fill}
+% %
+% % \vspace{-0.45cm}
+% % geometric impedance + resistive wall (with and without NEG)
+% \imagexywcenter{3.47}{3.5}{0.45\textwidth}{"plots/2nd_fill/energy_spread_over_current_reduced.png"}
+%
+% \textxy{9}{5.5}{\parbox{1\textwidth}{imag}}
+%
+% \end{frame}
+
+
+
+
+\end{document}

first_slides/2024-01_proposal.toc

@@ -0,0 +1 @@
+\babel@toc {nil}{}\relax 

gegenuberstellung_vorher_nachher.txt

@@ -0,0 +1,13 @@
+vorher = Status quo
+
+RT important
+promising FLASH
+- not yet in clinical settings
+-just now first clinical standard?
+-not easy as accelerator based and most clinical linacs not sufficient
+- still much work to be done in metrology(dosimetry and quality control), required for reliability in deposited dose
+e.g. deviation between measured dose and simulated, (one side is due to effects in detector, other might be due to additional effects in beam transport not considered until now)
+-not yet clear what exactly are the optimal parameters when it comes to pulse shortness and high dose
+
+
+and microbeam, mainly with x-ray, as electron beams diverge fast, but similar potential as flash to spare healthy tissue

outputs.txt

@@ -0,0 +1,56 @@
+output
+
+
+In my previous work experience, I have been deeply involved in the study of collective effects and instabilities influencing electron bunch shape in all dimensions. My research has primarily focused on extreme operation modes such as high charge, small transverse bunch size, short bunch length, and sub-structures to better understand the underlying phenomena occurring within these conditions.
+
+My work has been predominantly conducted on storage rings but with a strong emphasis on single bunch effects that can be directly applied to linear accelerators (linacs). To investigate these complex dynamics, I have developed extensive simulation capabilities in nonlinear optics and beam dynamics while also conducting comprehensive experimental studies and measurements.
+
+To gather data from the intricate experiments, I utilized various diagnostic tools such as electron-beam based detectors and synchrotron radiation-based diagnostics like THz-Schottky diode detectors. Additionally, I have developed and improved existing diagnostic methods to obtain a more accurate understanding of the phenomena at hand.
+
+In my work, I frequently dealt with large datasets that required advanced data analysis techniques using tools such as Python and high performance computing (HPC). This allowed me to efficiently process and interpret complex information for further research and development purposes.
+
+One notable aspect of my previous experience involved participating in the development and benchmarking/testing of new simulation methods, specifically focusing on a Vlasov-Fokker-Planck solver that is based on charge distribution within longitudinal phase space. This work has contributed to our understanding of collective effects in electron bunches and their potential implications for future accelerator technologies.
+
+
+--------------------
+Your previous work experience has been extensive and varied, focusing primarily on the intricate aspects of electron bunch behavior under extreme conditions. Your research interests have spanned both theoretical and experimental investigations, encompassing a wide range of topics including collective effects, nonlinear optics, and beam dynamics. This multifaceted background allows you to approach problems from diverse angles, which has proven invaluable when working on projects that require the understanding of complex phenomena occurring within high-energy accelerators.
+
+Throughout your career, you have gained valuable experience in both ring-based and linac-focused research environments. This adaptability and breadth of knowledge has made you a sought-after expert in the field. Your work has centered on understanding how single bunch effects can be translated to larger accelerator systems for improved performance and stability.
+
+In addition to your theoretical pursuits, you have also conducted extensive experimental studies and measurements. By employing state-of-the-art diagnostic tools such as electron-beam based detectors and synchrotron radiation based diagnostics (e.g., THz-Schottky diode detectors), you have been able to gather critical data on the behavior of electrons in these extreme conditions. This information has not only informed your research but also driven the development of new diagnostic methods for more accurate and comprehensive analysis.
+
+Furthermore, your experience with handling large datasets and complex analyses has equipped you with a strong foundation in high-performance computing (HPC) and Python programming. These skills have been instrumental in refining your ability to sift through immense amounts of data and extract meaningful insights that can inform the development of new simulation tools and techniques.
+
+One notable contribution during your career was the involvement in developing and benchmarking/testing a novel Vlasov-Fokker-Planck solver based on charge distribution in longitudinal phase-space. This innovative approach has opened up exciting avenues for future research, as it allows for more accurate simulations of electron bunch behavior under extreme conditions.
+
+In summary, your diverse and interdisciplinary background in the field of high-energy accelerators makes you an ideal candidate to drive forward cutting-edge research projects. Your expertise spans from understanding complex collective effects and nonlinear optics to developing advanced diagnostic tools for more accurate data analysis. This unique combination of skills positions you at the forefront of scientific exploration, with a passion for uncovering new knowledge in this rapidly evolving field.
+
+(Write a few paragraphs describing my previous work experience which is given in the following bullet points
+
+- experience in longitudinal as well as transverse collective effects and instabilities
+influencing the electron bunch shape in all dimensions
+- in general, investigating phenomena occurring under extreme operation modes, e.g. high
+charge, small transverse bunch-size, short bunch-length, sub-structures, ...
+- on rings but focused on single bunch effects transferrable to linacs
+- simulations of non-linear optics and beam dynamics, collective effects
+- extensive experimental studies and measurements
+- used diagnostics: electron-beam based as well as synchrotron-radiation based (e.g. THz-Schottky diode detectors...)
+as well as improved and further-developed diagnostic methods
+- data analysis of complex, big datasets with, among others, Python and HPC (high
+performance computing
+- involve in development and benchmarking/test of new simulation, vlasov-fokker-planck solver based on charge distribution in longitudinal phase-space  )
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+My previous work experience involved investigating phenomena occurring under extreme operation modes in electron accelerators. I have extensive knowledge in longitudinal as well as transverse collective effects and instabilities that influence the electron bunch shape in all dimensions. I worked on single bunch effects transferrable to linacs, simulations of non-linear optics and beam dynamics, collective effects, and experimental studies using diagnostics such as electron-beam based and synchrotron-radiation based detectors like THz-Schottky diode detectors.
+I have experience in developing and benchmarking/test of new simulation solvers for charge distribution in longitudinal phase-space. My work involved analyzing complex, big datasets using Python and HPC (high performance computing) to draw meaningful insights from the data. I also contributed to the development of improved diagnostic methods for electron accelerators.
+Overall, my previous work experience has equipped me with a strong foundation in understanding and working with electron accelerator technology, simulation tools, and experimental techniques. This knowledge will be valuable as I continue to pursue research and development opportunities in this field.
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+As a dedicated researcher, I have been actively involved in various projects that focus on understanding the complex behavior of electron bunches under extreme operation modes. My work experience includes investigating collective effects and instabilities in both longitudinal and transverse dimensions, which are crucial for optimizing performance in particle accelerators.
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+My primary area of expertise is in non-linear optics and beam dynamics, where I have conducted extensive experimental studies to measure the phenomena occurring under high charge, small transverse bunch size, short bunch length, and sub-structures within electron bunches. This work has been crucial for improving our understanding of how these factors influence the overall performance of accelerators.
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+In addition to my research, I have also developed and improved diagnostic methods that are essential for accurately measuring and analyzing complex datasets. These diagnostics include both electron-beam based techniques as well as synchrotron radiation-based approaches, such as THz-Schottky diode detectors. By utilizing advanced tools like Python and high performance computing (HPC), I have been able to analyze large amounts of data effectively and efficiently.
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+Furthermore, I have been involved in the development and benchmarking/testing of new simulation methods, specifically focusing on a Vlasov-Fokker-Planck solver that is based on charge distribution within longitudinal phase space. This work has allowed me to contribute significantly to our understanding of electron bunch behavior under extreme conditions and will ultimately help improve the performance of future particle accelerators.